DHX38 [The Human Chemical-Genetic Interaction Map Project]

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======= DHX38 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: DHX38
  * **<color #00a2e8>Official Name</color>**: DEAH-box helicase 38
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9785|9785]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q92620|Q92620]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=DHX38&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20DHX38|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605584|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. The protein encoded by this gene is a member of the DEAD/H box family of splicing factors. This protein resembles yeast Prp16 more closely than other DEAD/H family members. It is an ATPase and essential for the catalytic step II in pre-mRNA splicing process. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Probable ATP-binding RNA helicase involved in pre-mRNA splicing.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|DEAD|
|OB NTP bind|
|HA2|
|Helicase C|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|3-5 RNA helicase activity|
|mRNA 3-end processing|
|catalytic step 2 spliceosome|
|mRNA-containing ribonucleoprotein complex export from nucleus|
|mRNA export from nucleus|
|ribonucleoprotein complex export from nucleus|
|ribonucleoprotein complex localization|
|RNA export from nucleus|
|RNA 3-end processing|
|protein export from nucleus|
|mRNA transport|
|nuclear export|
|RNA transport|
|nucleic acid transport|
|establishment of RNA localization|
|RNA localization|
|nucleobase-containing compound transport|
|protein-containing complex localization|
|nucleocytoplasmic transport|
|nuclear transport|
|RNA splicing, via transesterification reactions with bulged adenosine as nucleophile|
|mRNA splicing, via spliceosome|
|RNA splicing, via transesterification reactions|
|RNA splicing|
|mRNA processing|
|mRNA metabolic process|
|RNA processing|
|intracellular protein transport|
|RNA binding|
|ATP binding|
|protein transport|
|intracellular transport|
|peptide transport|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|RNA metabolic process|
|establishment of localization in cell|
|nitrogen compound transport|
|membrane|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp448|Ammonium tetrathiomolybdate 10μM R08 exp448]]|-2.33|
|[[:results:exp7|Bortezomib 0.05μM R00 exp7]]|-2.16|
|[[:results:exp66|BI-D1870 3.15μM R02 exp66]]|-1.99|
|[[:results:exp507|Monensin 0.3μM R08 exp507]]|-1.77|
|[[:results:exp358|FK-506 5μM R07 exp358]]|1.71|
|[[:results:exp241|QNZ 0.01μM R05 exp241]]|1.72|
|[[:results:exp453|B02 10μM R08 exp453]]|1.75|
|[[:results:exp227|Cryptotanshinone 12μM R05 exp227]]|1.76|
|[[:results:exp283|Glyphosate 1000μM R06 exp283]]|1.83|
|[[:results:exp125|GSK461364A 0.005μM R03 exp125]]|1.86|
|[[:results:exp303|39°C R06 exp303]]|1.98|
|[[:results:exp260|ABT-702 0.1μM R06 exp260]]|2.03|
|[[:results:exp317|Geldanamycin 0.015 to 0.05μM on day4 R07 exp317]]|2.05|
|[[:results:exp229|Dimethyloxaloylglycine 100μM R05 exp229]]|2.06|
|[[:results:exp73|LJH685 5μM R02 exp73]]|2.11|
|[[:results:exp220|BAY-598 4μM R05 exp220]]|2.16|
|[[:results:exp177|Apcin 25μM plus proTAME 2μM R04 exp177]]|2.17|
|[[:results:exp209|Deguelin 0.15μM R05 exp209]]|2.18|
|[[:results:exp285|GW501516 25μM R06 exp285]]|2.18|
|[[:results:exp234|Ethanol 0.01 R05 exp234]]|2.4|
|[[:results:exp425|Beta-Estradiol 0.55μM R07 exp425]]|2.45|
|[[:results:exp286|HMS-I2 1μM R06 exp286]]|2.66|
|[[:results:exp375|Lenalidomide 20μM R07 exp375]]|2.69|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:psmb4|PSMB4]]|0.499|
|[[:human genes:p:psma6|PSMA6]]|0.495|
|[[:human genes:c:chd4|CHD4]]|0.494|
|[[:human genes:t:tsg101|TSG101]]|0.492|
|[[:human genes:g:gid4|GID4]]|0.488|
|[[:human genes:z:znf830|ZNF830]]|0.488|
|[[:human genes:t:tbc1d3f|TBC1D3F]]|0.482|
|[[:human genes:v:vps28|VPS28]]|0.481|
|[[:human genes:d:ddtl|DDTL]]|0.478|
|[[:human genes:r:rps2|RPS2]]|0.477|
|[[:human genes:p:polr2j3|POLR2J3]]|0.476|
|[[:human genes:a:apc2|APC2]]|0.469|
|[[:human genes:f:fam160a1|FAM160A1]]|0.468|
|[[:human genes:t:tceb3c|TCEB3C]]|0.467|
|[[:human genes:m:myh7b|MYH7B]]|0.466|
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.464|
|[[:human genes:t:tp53tg3b|TP53TG3B]]|0.463|
|[[:human genes:t:tp53tg3|TP53TG3]]|0.463|
|[[:human genes:t:tp53tg3c|TP53TG3C]]|0.462|
|[[:human genes:t:tceb3cl|TCEB3CL]]|0.461|
|[[:human genes:a:aatf|AATF]]|0.46|
|[[:human genes:c:copa|COPA]]|0.459|
|[[:human genes:t:tyms|TYMS]]|0.455|
|[[:human genes:s:slc6a17|SLC6A17]]|0.455|
|[[:human genes:m:mtch2|MTCH2]]|0.454|
|[[:human genes:c:ctage4|CTAGE4]]|0.454|
|[[:human genes:c:cactin|CACTIN]]|0.453|
|[[:human genes:p:psmb2|PSMB2]]|0.453|
|[[:human genes:p:psma7|PSMA7]]|0.45|
|[[:human genes:n:narfl|NARFL]]|0.448|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.447|
|[[:human genes:l:lrr1|LRR1]]|0.446|
|[[:human genes:x:xylt2|XYLT2]]|0.445|
|[[:human genes:a:aqr|AQR]]|0.445|
|[[:human genes:m:mt1e|MT1E]]|0.443|
|[[:human genes:r:rpl6|RPL6]]|0.443|
|[[:human genes:c:copg1|COPG1]]|0.442|
|[[:human genes:d:dtl|DTL]]|0.442|
|[[:human genes:f:fam25b|FAM25B]]|0.441|
|[[:human genes:e:exosc8|EXOSC8]]|0.441|
|[[:human genes:u:utp3|UTP3]]|0.44|
|[[:human genes:c:c1qtnf9b|C1QTNF9B]]|0.44|
|[[:human genes:b:brd2|BRD2]]|0.44|
|[[:human genes:t:ticrr|TICRR]]|0.438|
|[[:human genes:o:osbp|OSBP]]|0.438|
|[[:human genes:k:kctd17|KCTD17]]|0.437|
|[[:human genes:p:pan3|PAN3]]|0.437|
|[[:human genes:p:psmd3|PSMD3]]|0.435|
|[[:human genes:t:tbc1d3|TBC1D3]]|0.434|
|[[:human genes:p:psmd11|PSMD11]]|0.433|
|[[:human genes:s:sh3bp1|SH3BP1]]|0.433|
|[[:human genes:c:col2a1|COL2A1]]|0.428|
|[[:human genes:s:slc4a1|SLC4A1]]|0.428|
|[[:human genes:c:cdt1|CDT1]]|0.427|
|[[:human genes:c:cep192|CEP192]]|0.426|
|[[:human genes:i:ik|IK]]|0.425|
|[[:human genes:r:rpl35|RPL35]]|0.425|
|[[:human genes:r:rfc1|RFC1]]|0.425|
|[[:human genes:c:chaf1a|CHAF1A]]|0.424|
|[[:human genes:t:twistnb|TWISTNB]]|0.421|
|[[:human genes:r:rnf113a|RNF113A]]|0.42|
|[[:human genes:p:psmc1|PSMC1]]|0.419|
|[[:human genes:r:rrn3|RRN3]]|0.418|
|[[:human genes:n:napa|NAPA]]|0.418|
|[[:human genes:a:ankle1|ANKLE1]]|0.417|
|[[:human genes:d:dimt1|DIMT1]]|0.416|
|[[:human genes:c:copb1|COPB1]]|0.416|
|[[:human genes:a:akirin2|AKIRIN2]]|0.414|
|[[:human genes:g:golga6l3|GOLGA6L3]]|0.413|
|[[:human genes:c:ccna2|CCNA2]]|0.413|
|[[:human genes:p:prpf19|PRPF19]]|0.413|
|[[:human genes:n:npipb5|NPIPB5]]|0.412|
|[[:human genes:p:pole|POLE]]|0.412|
|[[:human genes:t:tbc1d3g|TBC1D3G]]|0.411|
|[[:human genes:c:cdc45|CDC45]]|0.41|
|[[:human genes:r:rrp7a|RRP7A]]|0.41|
|[[:human genes:e:exosc6|EXOSC6]]|0.41|
|[[:human genes:t:tfip11|TFIP11]]|0.41|
|[[:human genes:e:exosc3|EXOSC3]]|0.409|
|[[:human genes:c:cbwd5|CBWD5]]|0.408|
|[[:human genes:t:tspy2|TSPY2]]|0.408|
|[[:human genes:d:ddt|DDT]]|0.407|
|[[:human genes:s:sec13|SEC13]]|0.406|
|[[:human genes:a:akt1s1|AKT1S1]]|0.406|
|[[:human genes:m:mdn1|MDN1]]|0.405|
|[[:human genes:a:acbd4|ACBD4]]|0.405|
|[[:human genes:r:rrp15|RRP15]]|0.404|
|[[:human genes:r:ranbp2|RANBP2]]|0.404|
|[[:human genes:s:sf3a3|SF3A3]]|0.404|
|[[:human genes:z:zfand5|ZFAND5]]|0.403|
|[[:human genes:g:gltscr2|GLTSCR2]]|0.401|
|[[:human genes:c:c2orf27b|C2orf27B]]|0.401|
|[[:human genes:a:atp6v1b2|ATP6V1B2]]|0.4|
|[[:human genes:r:rps12|RPS12]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 7/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|1/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|1/21|
|liver|0/20|
|lung|1/75|
|lymphocyte|0/14|
|ovary|1/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|1/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 702
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.77 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='DHX38 Expression in NALM6 Cells: 6.77'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>