ADCYAP1R1

Gene Information

Official Symbol: ADCYAP1R1
Official Name: ADCYAP receptor type I
Aliases and Previous Symbols: N/A
Entrez ID: 117
UniProt: P41586
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes type I adenylate cyclase activating polypeptide receptor, which is a membrane-associated protein and shares significant homology with members of the glucagon/secretin receptor family. This receptor mediates diverse biological actions of adenylate cyclase activating polypeptide 1 and is positively coupled to adenylate cyclase. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Dec 2010].
UniProt Summary: This is a receptor for PACAP-27 and PACAP-38. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. May regulate the release of adrenocorticotropin, luteinizing hormone, growth hormone, prolactin, epinephrine, and catecholamine. May play a role in spermatogenesis and sperm motility. Causes smooth muscle relaxation and secretion in the gastrointestinal tract.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Taxol 0.004μM R03 exp103	-2.33
Tunicamycin 0.04μM R07 exp418	-2.19
Phenformin 20μM R05 exp212	-1.9
Dorsomorphin 5μM R07 exp357	-1.73
ABT-702 5μM plus Deferoxamine 11μM R07 exp321	1.71
Tanespimycin 14μM R08 exp527	2.09
BS-181 20μM R08 exp461	2.2
SNS-032 15μM R08 exp443	2.44
Nocodazole 0.2μM R02 exp64	2.51
Rotenone 2μM R00 exp33	2.57
Nocodazole 0.1μM R03 exp94	2.62
HMS-I1 10μM R06 exp256	2.84
SB743921 0.001μM R05 exp244	3.06
DABN racemic mixture R03 exp93	3.12
R-DABN 8μM R03 exp111	3.75
Nocodazole 0.2μM R00 exp24	4.25

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 17951
Expression level (log2 read counts): -1.56

Expression Distribution

HRM
7tm 2

vasoactive intestinal polypeptide receptor activity
ADP-ribosylation factor binding
adenylate cyclase binding
positive regulation of inositol phosphate biosynthetic process
regulation of inositol phosphate biosynthetic process
neuropeptide binding
positive regulation of cAMP-mediated signaling
positive regulation of alcohol biosynthetic process
activation of phospholipase C activity
G protein-coupled peptide receptor activity
peptide hormone binding
positive regulation of phospholipase C activity
regulation of phospholipase C activity
regulation of cAMP-mediated signaling
positive regulation of calcium ion transport into cytosol
positive regulation of cellular carbohydrate metabolic process
positive regulation of phospholipase activity
rough endoplasmic reticulum
multicellular organismal response to stress
positive regulation of small GTPase mediated signal transduction
positive regulation of lipase activity
regulation of phospholipase activity
caveola
regulation of alcohol biosynthetic process
positive regulation of carbohydrate metabolic process
development of primary female sexual characteristics
regulation of carbohydrate biosynthetic process
regulation of lipase activity
regulation of calcium ion transport into cytosol
female sex differentiation
positive regulation of calcium ion transport
bicellular tight junction
response to ethanol
response to estradiol
positive regulation of small molecule metabolic process
regulation of cellular carbohydrate metabolic process
cAMP-mediated signaling
cyclic-nucleotide-mediated signaling
signaling receptor activity
receptor complex