RGMA

Gene Information

Official Symbol: RGMA
Official Name: repulsive guidance molecule BMP co-receptor a
Aliases and Previous Symbols: N/A
Entrez ID: 56963
UniProt: Q96B86
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: N/A

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 9546
Expression level (log2 read counts): 4.67

Expression Distribution

Screen	Score
R-DABN 8μM R03 exp111	-2.11
CCT251545 20μM R07 exp326	-1.82

RGM C
RGM N

transferrin receptor binding
negative regulation of axon regeneration
negative regulation of neuron projection regeneration
regulation of axon regeneration
regulation of neuron projection regeneration
coreceptor activity
negative regulation of response to wounding
BMP signaling pathway
anchored component of membrane
response to BMP
cellular response to BMP stimulus
negative regulation of neuron projection development
regulation of response to wounding
negative regulation of cell projection organization
transmembrane receptor protein serine/threonine kinase signaling pathway
negative regulation of neuron differentiation
negative regulation of neurogenesis
negative regulation of nervous system development
negative regulation of cell development
negative regulation of response to external stimulus
regulation of neuron projection development
cellular response to growth factor stimulus
response to growth factor
regulation of neuron differentiation
regulation of plasma membrane bounded cell projection organization
negative regulation of cellular component organization
regulation of cell projection organization
negative regulation of cell differentiation
enzyme linked receptor protein signaling pathway
regulation of cellular response to stress
regulation of neurogenesis
regulation of nervous system development
regulation of cell development
negative regulation of developmental process
endoplasmic reticulum
regulation of response to external stimulus
negative regulation of multicellular organismal process
positive regulation of transcription by RNA polymerase II
cellular response to endogenous stimulus
response to endogenous stimulus