MAD2L1BP

Entrez Summary: N/A
UniProt Summary: May function to silence the spindle checkpoint and allow mitosis to proceed through anaphase by binding MAD2L1 after it has become dissociated from the MAD2L1-CDC20 complex. {ECO:0000269|PubMed:18022368}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 6/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	1/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	1/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	1/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	2/22
urinary tract	1/29
uterus	0/5

Expression Distribution

regulation of exit from mitosis
spindle
mitotic cell cycle checkpoint
regulation of mitotic nuclear division
regulation of nuclear division
cell cycle checkpoint
nuclear membrane
negative regulation of mitotic cell cycle
regulation of mitotic cell cycle phase transition
regulation of cell cycle phase transition
negative regulation of cell cycle
mitotic cell cycle process
regulation of mitotic cell cycle
mitotic cell cycle
regulation of cell cycle process
nucleolus
cell cycle process
regulation of cell cycle
regulation of organelle organization
cell cycle