MAD2L1BP [The Human Chemical-Genetic Interaction Map Project]

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======= MAD2L1BP =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MAD2L1BP
  * **<color #00a2e8>Official Name</color>**: MAD2L1 binding protein
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9587|9587]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q15013|Q15013]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MAD2L1BP&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MAD2L1BP|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/618136|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  May function to silence the spindle checkpoint and allow mitosis to proceed through anaphase by binding MAD2L1 after it has become dissociated from the MAD2L1-CDC20 complex. {ECO:0000269|PubMed:18022368}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|p31comet|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of exit from mitosis|
|spindle|
|mitotic cell cycle checkpoint|
|regulation of mitotic nuclear division|
|regulation of nuclear division|
|cell cycle checkpoint|
|nuclear membrane|
|negative regulation of mitotic cell cycle|
|regulation of mitotic cell cycle phase transition|
|regulation of cell cycle phase transition|
|negative regulation of cell cycle|
|mitotic cell cycle process|
|regulation of mitotic cell cycle|
|mitotic cell cycle|
|regulation of cell cycle process|
|nucleolus|
|cell cycle process|
|regulation of cell cycle|
|regulation of organelle organization|
|cell cycle|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp187|proTAME 5μM R04 exp187]]|-3.96|
|[[:results:exp177|Apcin 25μM plus proTAME 2μM R04 exp177]]|-2.95|
|[[:results:exp190|Vincristine 0.0005μM R04 exp190]]|-1.91|
|[[:results:exp176|Apcin 50 to 100μM on day4 R04 exp176]]|-1.73|
|[[:results:exp17|DABN 20μM R00 exp17]]|2|
|[[:results:exp256|HMS-I1 10μM R06 exp256]]|2.84|
|[[:results:exp108|Vinblastine 0.2μM R03 exp108]]|3.4|
|[[:results:exp64|Nocodazole 0.2μM R02 exp64]]|3.79|
|[[:results:exp244|SB743921 0.001μM R05 exp244]]|4.16|
|[[:results:exp208|Vinblastine 0.015μM R05 exp208]]|4.35|
|[[:results:exp93|DABN racemic mixture R03 exp93]]|4.93|
|[[:results:exp111|R-DABN 8μM R03 exp111]]|5.07|
|[[:results:exp24|Nocodazole 0.2μM R00 exp24]]|5.21|
|[[:results:exp94|Nocodazole 0.1μM R03 exp94]]|5.51|
|[[:results:exp33|Rotenone 2μM R00 exp33]]|5.91|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:t:trip13|TRIP13]]|0.858|
|[[:human genes:k:kntc1|KNTC1]]|0.759|
|[[:human genes:z:zw10|ZW10]]|0.743|
|[[:human genes:z:zwilch|ZWILCH]]|0.735|
|[[:human genes:m:mad1l1|MAD1L1]]|0.683|
|[[:human genes:b:bub1b|BUB1B]]|0.656|
|[[:human genes:r:rbm14|RBM14]]|0.655|
|[[:human genes:m:mad2l1|MAD2L1]]|0.65|
|[[:human genes:b:bub3|BUB3]]|0.621|
|[[:human genes:c:cdc20|CDC20]]|0.587|
|[[:human genes:f:fntb|FNTB]]|0.522|
|[[:human genes:f:fnta|FNTA]]|0.481|
|[[:human genes:u:ube2s|UBE2S]]|0.418|
|[[:human genes:c:cenpe|CENPE]]|0.416|
|[[:human genes:c:ccnb1|CCNB1]]|0.41|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 6/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|1/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|1/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|1/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|2/22|
|urinary tract|1/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3000
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.74 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MAD2L1BP Expression in NALM6 Cells: 4.74'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>