TRAPPC4

Entrez Summary: N/A
UniProt Summary: May play a role in vesicular transport from endoplasmic reticulum to Golgi.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Mubritinib 0.2μM R01 exp48	-2.72
R-DABN 8μM R03 exp111	-2.19
Suberoylanilide-Hydroxamic-Acid 0.02μM R01 exp53	-2.17
42°C R08 exp539	-1.99
TGF-beta1 44ng/ml R08 exp528	-1.94
All-trans-Retinoic-Acid 8μM R07 exp333	-1.87
Cerivastatin 0.15μM R05 exp226	-1.82
Rapamycin 2μM R07 exp306	-1.82

Global Fraction of Cell Lines Where Essential: 689/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	1/1
bile duct	27/28
blood	26/28
bone	24/26
breast	31/33
central nervous system	52/56
cervix	4/4
colorectal	15/17
esophagus	13/13
fibroblast	1/1
gastric	16/16
kidney	20/21
liver	19/20
lung	65/75
lymphocyte	15/16
ovary	25/26
pancreas	19/24
peripheral nervous system	16/16
plasma cell	15/15
prostate	0/1
skin	22/24
soft tissue	8/9
thyroid	2/2
upper aerodigestive	21/22
urinary tract	27/29
uterus	4/5

Expression Distribution

Sybindin
Sedlin N

TRAPP complex
Golgi stack
Rab guanyl-nucleotide exchange factor activity
vesicle targeting, rough ER to cis-Golgi
COPII vesicle coating
vesicle coating
COPII-coated vesicle budding
vesicle targeting, to, from or within Golgi
Golgi vesicle budding
vesicle targeting
vesicle budding from membrane
dendrite development
synaptic vesicle
establishment of vesicle localization
vesicle localization
endoplasmic reticulum to Golgi vesicle-mediated transport
synapse
vesicle organization
establishment of organelle localization
Golgi vesicle transport
dendrite
organelle localization
Golgi membrane
neuron projection development
neuron development
membrane organization
neuron differentiation
endoplasmic reticulum
plasma membrane bounded cell projection organization
cell projection organization
intracellular transport
generation of neurons
protein-containing complex assembly
neurogenesis
cell development
establishment of localization in cell
protein-containing complex subunit organization
vesicle-mediated transport