TRAPPC4 [The Human Chemical-Genetic Interaction Map Project]

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======= TRAPPC4 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TRAPPC4
  * **<color #00a2e8>Official Name</color>**: trafficking protein particle complex 4
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=51399|51399]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9Y296|Q9Y296]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TRAPPC4&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TRAPPC4|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/610971|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  May play a role in vesicular transport from endoplasmic reticulum to Golgi.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Sybindin|
|Sedlin N|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|TRAPP complex|
|Golgi stack|
|Rab guanyl-nucleotide exchange factor activity|
|vesicle targeting, rough ER to cis-Golgi|
|COPII vesicle coating|
|vesicle coating|
|COPII-coated vesicle budding|
|vesicle targeting, to, from or within Golgi|
|Golgi vesicle budding|
|vesicle targeting|
|vesicle budding from membrane|
|dendrite development|
|synaptic vesicle|
|establishment of vesicle localization|
|vesicle localization|
|endoplasmic reticulum to Golgi vesicle-mediated transport|
|synapse|
|vesicle organization|
|establishment of organelle localization|
|Golgi vesicle transport|
|dendrite|
|organelle localization|
|Golgi membrane|
|neuron projection development|
|neuron development|
|membrane organization|
|neuron differentiation|
|endoplasmic reticulum|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|intracellular transport|
|generation of neurons|
|protein-containing complex assembly|
|neurogenesis|
|cell development|
|establishment of localization in cell|
|protein-containing complex subunit organization|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp48|Mubritinib 0.2μM R01 exp48]]|-2.72|
|[[:results:exp111|R-DABN 8μM R03 exp111]]|-2.19|
|[[:results:exp53|Suberoylanilide-Hydroxamic-Acid 0.02μM R01 exp53]]|-2.17|
|[[:results:exp539|42°C R08 exp539]]|-1.99|
|[[:results:exp528|TGF-beta1 44ng/ml R08 exp528]]|-1.94|
|[[:results:exp333|All-trans-Retinoic-Acid 8μM R07 exp333]]|-1.87|
|[[:results:exp226|Cerivastatin 0.15μM R05 exp226]]|-1.82|
|[[:results:exp306|Rapamycin 2μM R07 exp306]]|-1.82|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 689/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|27/28|
|blood|26/28|
|bone|24/26|
|breast|31/33|
|central nervous system|52/56|
|cervix|4/4|
|colorectal|15/17|
|esophagus|13/13|
|fibroblast|1/1|
|gastric|16/16|
|kidney|20/21|
|liver|19/20|
|lung|65/75|
|lymphocyte|15/16|
|ovary|25/26|
|pancreas|19/24|
|peripheral nervous system|16/16|
|plasma cell|15/15|
|prostate|0/1|
|skin|22/24|
|soft tissue|8/9|
|thyroid|2/2|
|upper aerodigestive|21/22|
|urinary tract|27/29|
|uterus|4/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1387
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.42 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TRAPPC4 Expression in NALM6 Cells: 5.42'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>