UQCR10 [The Human Chemical-Genetic Interaction Map Project]

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======= UQCR10 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: UQCR10
  * **<color #00a2e8>Official Name</color>**: ubiquinol-cytochrome c reductase, complex III subunit X
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=29796|29796]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9UDW1|Q9UDW1]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=UQCR10&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20UQCR10|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/610843|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. This subunit interacts with cytochrome c1 (By similarity). {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|UCR UQCRX QCR9|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|mitochondrial respiratory chain complex III assembly|
|respiratory chain complex III assembly|
|ubiquinol-cytochrome-c reductase activity|
|mitochondrial respiratory chain complex III|
|mitochondrial electron transport, ubiquinol to cytochrome c|
|cytochrome complex assembly|
|aerobic respiration|
|mitochondrial ATP synthesis coupled electron transport|
|ATP synthesis coupled electron transport|
|mitochondrial respiratory chain complex assembly|
|respiratory electron transport chain|
|oxidative phosphorylation|
|cellular respiration|
|electron transport chain|
|ATP metabolic process|
|energy derivation by oxidation of organic compounds|
|mitochondrial inner membrane|
|generation of precursor metabolites and energy|
|mitochondrion organization|
|cellular protein-containing complex assembly|
|oxidation-reduction process|
|phosphorylation|
|protein-containing complex assembly|
|protein-containing complex subunit organization|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp191|Hypoxia 5%O2 R04 exp191]]|-2.86|
|[[:results:exp472|CI-1040 9.5μM R08 exp472]]|1.72|
|[[:results:exp487|Hinokiflavone 12μM R08 exp487]]|1.72|
|[[:results:exp527|Tanespimycin 14μM R08 exp527]]|1.75|
|[[:results:exp492|iCRT14 30μM R08 exp492]]|1.8|
|[[:results:exp448|Ammonium tetrathiomolybdate 10μM R08 exp448]]|1.99|
|[[:results:exp503|Mitomycin-C 0.06μM R08 exp503]]|2.3|
|[[:results:exp513|ONC212 0.15μM R08 exp513]]|2.32|
|[[:results:exp469|CFI-400945 25μM R08 exp469]]|2.4|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:k:kiaa0391|KIAA0391]]|0.572|
|[[:human genes:b:bcs1l|BCS1L]]|0.57|
|[[:human genes:m:mrpl21|MRPL21]]|0.566|
|[[:human genes:t:tufm|TUFM]]|0.561|
|[[:human genes:s:sars2|SARS2]]|0.542|
|[[:human genes:m:mrps34|MRPS34]]|0.536|
|[[:human genes:y:yars2|YARS2]]|0.533|
|[[:human genes:h:hsd17b10|HSD17B10]]|0.531|
|[[:human genes:c:cox16|COX16]]|0.528|
|[[:human genes:s:selrc1|SELRC1]]|0.527|
|[[:human genes:m:mrps5|MRPS5]]|0.526|
|[[:human genes:m:mrps18a|MRPS18A]]|0.524|
|[[:human genes:m:mrps14|MRPS14]]|0.522|
|[[:human genes:m:mrps24|MRPS24]]|0.516|
|[[:human genes:d:dap3|DAP3]]|0.515|
|[[:human genes:m:mrps21|MRPS21]]|0.513|
|[[:human genes:m:mrps2|MRPS2]]|0.512|
|[[:human genes:s:supv3l1|SUPV3L1]]|0.505|
|[[:human genes:m:mrp63|MRP63]]|0.503|
|[[:human genes:t:tefm|TEFM]]|0.501|
|[[:human genes:m:mrps9|MRPS9]]|0.501|
|[[:human genes:c:chchd4|CHCHD4]]|0.5|
|[[:human genes:v:vars2|VARS2]]|0.499|
|[[:human genes:t:trub2|TRUB2]]|0.492|
|[[:human genes:s:sco2|SCO2]]|0.489|
|[[:human genes:m:mtpap|MTPAP]]|0.485|
|[[:human genes:d:dars2|DARS2]]|0.48|
|[[:human genes:h:hars2|HARS2]]|0.477|
|[[:human genes:f:fastkd5|FASTKD5]]|0.473|
|[[:human genes:e:ears2|EARS2]]|0.47|
|[[:human genes:s:slc25a26|SLC25A26]]|0.469|
|[[:human genes:m:mrps16|MRPS16]]|0.467|
|[[:human genes:m:mrpl47|MRPL47]]|0.466|
|[[:human genes:u:uap1|UAP1]]|0.463|
|[[:human genes:m:mrpl23|MRPL23]]|0.463|
|[[:human genes:m:mrpl15|MRPL15]]|0.462|
|[[:human genes:c:c10orf2|C10orf2]]|0.462|
|[[:human genes:m:mrps26|MRPS26]]|0.462|
|[[:human genes:r:rpusd4|RPUSD4]]|0.46|
|[[:human genes:m:mrpl12|MRPL12]]|0.458|
|[[:human genes:e:elac2|ELAC2]]|0.458|
|[[:human genes:m:mrps6|MRPS6]]|0.458|
|[[:human genes:f:fars2|FARS2]]|0.457|
|[[:human genes:c:c17orf89|C17orf89]]|0.453|
|[[:human genes:g:gfm1|GFM1]]|0.453|
|[[:human genes:m:mrpl53|MRPL53]]|0.452|
|[[:human genes:n:nars2|NARS2]]|0.451|
|[[:human genes:m:mrpl44|MRPL44]]|0.45|
|[[:human genes:c:cox7b|COX7B]]|0.45|
|[[:human genes:p:pdss1|PDSS1]]|0.448|
|[[:human genes:c:cox6c|COX6C]]|0.446|
|[[:human genes:r:rbfa|RBFA]]|0.443|
|[[:human genes:m:mrps33|MRPS33]]|0.443|
|[[:human genes:p:pars2|PARS2]]|0.443|
|[[:human genes:n:ndufb11|NDUFB11]]|0.443|
|[[:human genes:m:mrps17|MRPS17]]|0.44|
|[[:human genes:g:gtpbp10|GTPBP10]]|0.439|
|[[:human genes:m:mrpl55|MRPL55]]|0.437|
|[[:human genes:v:vezt|VEZT]]|0.437|
|[[:human genes:l:lars2|LARS2]]|0.436|
|[[:human genes:u:uqcrc2|UQCRC2]]|0.436|
|[[:human genes:u:uqcrq|UQCRQ]]|0.435|
|[[:human genes:r:rpia|RPIA]]|0.433|
|[[:human genes:m:mrps25|MRPS25]]|0.431|
|[[:human genes:r:rnaseh1|RNASEH1]]|0.431|
|[[:human genes:e:eif3f|EIF3F]]|0.43|
|[[:human genes:h:hccs|HCCS]]|0.428|
|[[:human genes:t:thg1l|THG1L]]|0.428|
|[[:human genes:t:tars2|TARS2]]|0.428|
|[[:human genes:n:ndufa3|NDUFA3]]|0.427|
|[[:human genes:m:mrpl42|MRPL42]]|0.426|
|[[:human genes:m:mrpl20|MRPL20]]|0.425|
|[[:human genes:t:tmem242|TMEM242]]|0.423|
|[[:human genes:m:mrps12|MRPS12]]|0.422|
|[[:human genes:n:ndufb3|NDUFB3]]|0.421|
|[[:human genes:m:mrps10|MRPS10]]|0.421|
|[[:human genes:t:txnl4b|TXNL4B]]|0.419|
|[[:human genes:u:uqcrc1|UQCRC1]]|0.416|
|[[:human genes:v:vps41|VPS41]]|0.415|
|[[:human genes:q:qrsl1|QRSL1]]|0.415|
|[[:human genes:p:pnpt1|PNPT1]]|0.414|
|[[:human genes:c:cycs|CYCS]]|0.414|
|[[:human genes:g:gfm2|GFM2]]|0.413|
|[[:human genes:a:atic|ATIC]]|0.412|
|[[:human genes:c:cox15|COX15]]|0.412|
|[[:human genes:a:alg13|ALG13]]|0.41|
|[[:human genes:m:mrpl33|MRPL33]]|0.409|
|[[:human genes:t:triap1|TRIAP1]]|0.408|
|[[:human genes:a:aasdhppt|AASDHPPT]]|0.408|
|[[:human genes:u:uqcrfs1|UQCRFS1]]|0.407|
|[[:human genes:p:ppcs|PPCS]]|0.406|
|[[:human genes:m:mrpl34|MRPL34]]|0.405|
|[[:human genes:m:mtg2|MTG2]]|0.405|
|[[:human genes:d:dohh|DOHH]]|0.405|
|[[:human genes:t:trmt61a|TRMT61A]]|0.405|
|[[:human genes:a:atp5b|ATP5B]]|0.405|
|[[:human genes:m:mars2|MARS2]]|0.404|
|[[:human genes:n:n6amt1|N6AMT1]]|0.404|
|[[:human genes:m:mrpl41|MRPL41]]|0.404|
|[[:human genes:p:ppa2|PPA2]]|0.403|
|[[:human genes:d:dhx30|DHX30]]|0.403|
|[[:human genes:d:dhrsx|DHRSX]]|0.402|
|[[:human genes:c:coq7|COQ7]]|0.401|
|[[:human genes:c:coa5|COA5]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 8/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|1/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|1/21|
|liver|0/20|
|lung|2/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|1/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|1/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3311
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.12 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='UQCR10 Expression in NALM6 Cells: 5.12'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>