RAB1B

Entrez Summary: N/A
UniProt Summary: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB1B regulates vesicular transport between the endoplasmic reticulum and successive Golgi compartments. Plays a role in the initial events of the autophagic vacuole development which take place at specialized regions of the endoplasmic reticulum. {ECO:0000269|PubMed:20545908, ECO:0000269|PubMed:9437002}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 2/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	1/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	1/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

establishment of endothelial intestinal barrier
phagophore assembly site membrane
positive regulation of glycoprotein metabolic process
establishment of endothelial barrier
regulation of autophagosome assembly
virion assembly
regulation of vacuole organization
regulation of glycoprotein metabolic process
endothelial cell development
COPII vesicle coating
vesicle targeting, rough ER to cis-Golgi
vesicle coating
COPII-coated vesicle budding
endoplasmic reticulum-Golgi intermediate compartment membrane
vesicle targeting, to, from or within Golgi
Rab protein signal transduction
Golgi vesicle budding
endothelial cell differentiation
retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum
vesicle targeting
transport vesicle
endothelium development
vesicle budding from membrane
regulation of macroautophagy
establishment of vesicle localization
vesicle localization
epithelial cell development
viral life cycle
endoplasmic reticulum to Golgi vesicle-mediated transport
regulation of organelle assembly
Ras protein signal transduction
autophagy
process utilizing autophagic mechanism
vesicle organization
small GTPase mediated signal transduction
GTPase activity
regulation of autophagy
post-translational protein modification
establishment of organelle localization
Golgi vesicle transport