SCYL1
Gene Information
- Official Symbol: SCYL1
- Official Name: SCY1 like pseudokinase 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 57410
- UniProt: Q96KG9
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene encodes a transcriptional regulator belonging to the SCY1-like family of kinase-like proteins. The protein has a divergent N-terminal kinase domain that is thought to be catalytically inactive, and can bind specific DNA sequences through its C-terminal domain. It activates transcription of the telomerase reverse transcriptase and DNA polymerase beta genes. The protein has been localized to the nucleus, and also to the cytoplasm and centrosomes during mitosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
- UniProt Summary: Regulates COPI-mediated retrograde protein traffic at the interface between the Golgi apparatus and the endoplasmic reticulum (PubMed:18556652). Involved in the maintenance of the Golgi apparatus morphology (PubMed:26581903). Has no detectable kinase activity in vitro (PubMed:18556652). {ECO:0000269|PubMed:18556652, ECO:0000269|PubMed:26581903}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 4663
- Expression level (log2 read counts): 5.71
SCYL1 Expression in NALM6 Cells: 5.71
