STK38

Gene Information

Official Symbol: STK38
Official Name: serine/threonine kinase 38
Aliases and Previous Symbols: N/A
Entrez ID: 11329
UniProt: Q15208
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Negative regulator of MAP3K1/2 signaling. Converts MAP3K2 from its phosphorylated form to its non-phosphorylated form and inhibits autophosphorylation of MAP3K2. {ECO:0000269|PubMed:12493777, ECO:0000269|PubMed:15197186, ECO:0000269|PubMed:17906693, ECO:0000269|PubMed:7761441}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
LB-100 4.1μM R02 exp72	-1.95
Q15 1 to 2μM on day4 R04 exp164	-1.83
∆-9-Tetrahydrocannabinol 30μM R08 exp445	-1.75
Radicicol 0.16μM R05 exp242	-1.74
ABT-702 5μM R07 exp318	1.8
L-74142 5μM R03 exp131	1.83
BI-2536 0.02μM R03 exp96	1.98
Azithromycin 100μM R08 exp452	2.14
PF-06409577 20μM R07 exp389	2.17
NFN1 1μM R03 exp100	2.23
SGC0649 7μM R03 exp150	2.24
Centrinone 0.5μM R07 exp343	2.41

Global Fraction of Cell Lines Where Essential: 0/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/25
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/14
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 8338
Expression level (log2 read counts): 7.68

Expression Distribution

Pkinase Tyr
Pkinase C
Pkinase

mitogen-activated protein kinase kinase kinase binding
negative regulation of MAP kinase activity
negative regulation of protein serine/threonine kinase activity
negative regulation of MAPK cascade
peptidyl-serine phosphorylation
peptidyl-serine modification
magnesium ion binding
negative regulation of protein kinase activity
negative regulation of kinase activity
negative regulation of transferase activity
cadherin binding
regulation of MAP kinase activity
protein serine/threonine kinase activity
negative regulation of protein phosphorylation
negative regulation of phosphorylation
negative regulation of intracellular signal transduction
regulation of protein serine/threonine kinase activity
negative regulation of phosphate metabolic process
negative regulation of phosphorus metabolic process
negative regulation of protein modification process
regulation of MAPK cascade
negative regulation of catalytic activity
regulation of protein kinase activity
regulation of kinase activity
peptidyl-amino acid modification
protein phosphorylation
regulation of transferase activity
negative regulation of cellular protein metabolic process
negative regulation of protein metabolic process
negative regulation of molecular function
negative regulation of signal transduction
phosphorylation
negative regulation of cell communication
negative regulation of signaling
regulation of protein phosphorylation
ATP binding
regulation of phosphorylation
negative regulation of response to stimulus
intracellular signal transduction
regulation of phosphate metabolic process