CUL4B

Gene Information

Official Symbol: CUL4B
Official Name: cullin 4B
Aliases and Previous Symbols: N/A
Entrez ID: 8450
UniProt: Q13620
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene is a member of the cullin family. The encoded protein forms a complex that functions as an E3 ubiquitin ligase and catalyzes the polyubiquitination of specific protein substrates in the cell. The protein interacts with a ring finger protein, and is required for the proteolysis of several regulators of DNA replication including chromatin licensing and DNA replication factor 1 and cyclin E. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
UniProt Summary: N/A

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 6/683

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	1/28
blood	0/26
bone	0/25
breast	1/30
central nervous system	1/49
cervix	0/4
colorectal	0/17
esophagus	0/11
fibroblast	0/1
gastric	0/14
kidney	0/18
liver	0/19
lung	1/72
lymphocyte	0/14
ovary	0/25
pancreas	0/22
peripheral nervous system	0/15
plasma cell	1/12
prostate	0/1
skin	0/20
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/28
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 15479
Expression level (log2 read counts): 5.81

Expression Distribution

Screen	Score
HMS-I1 10μM R06 exp256	-2.66
Hydroxyurea 15μM R06 exp289	-1.92
Vincristine 0.0005μM R04 exp190	1.79

Cullin Nedd8
Cullin

Cul4B-RING E3 ubiquitin ligase complex
cullin-RING ubiquitin ligase complex
UV-damage excision repair
histone H2A monoubiquitination
nucleotide-excision repair, preincision complex stabilization
nucleotide-excision repair, DNA incision, 3-to lesion
nucleotide-excision repair, DNA duplex unwinding
histone H2A ubiquitination
nucleotide-excision repair, DNA damage recognition
global genome nucleotide-excision repair
Cul4-RING E3 ubiquitin ligase complex
nucleotide-excision repair, preincision complex assembly
histone monoubiquitination
positive regulation of G1/S transition of mitotic cell cycle
nucleotide-excision repair, DNA incision, 5-to lesion
DNA damage response, detection of DNA damage
nucleotide-excision repair, DNA incision
histone ubiquitination
positive regulation of cell cycle G1/S phase transition
damaged DNA binding
protein monoubiquitination
SCF ubiquitin ligase complex
transcription-coupled nucleotide-excision repair
positive regulation of mitotic cell cycle phase transition
cellular response to UV
positive regulation of cell cycle phase transition
SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
nucleotide-excision repair
DNA duplex unwinding
cellular response to light stimulus
G1/S transition of mitotic cell cycle
DNA geometric change
cell cycle G1/S phase transition
response to UV
regulation of G1/S transition of mitotic cell cycle
positive regulation of mitotic cell cycle
regulation of cell cycle G1/S phase transition
cellular response to radiation
protein-DNA complex assembly
positive regulation of protein catabolic process