UBE3D

Entrez Summary: N/A
UniProt Summary: E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome. {ECO:0000269|PubMed:15749827}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Trimetrexate 0.03μM R08 exp535	-2.89
Hydroxyurea 15μM R06 exp289	-2.56
Hydroxyurea 100μM R07 exp329	-2.54
Nifuroxazide 1μM R01 exp51	-2.51
YM155 0.001μM R08 exp432	-2.28
Menadione 5μM R06 exp292	-2.18
Talazoparib 0.006μM R06 exp299	-2.14
Hypoxia 5%O2 R04 exp191	-2.03
L-BMAA 500 to 750μM on day4 R04 exp185	-1.92
UM0131023 0.05μM R05 exp248	-1.86
NFN1 1μM R03 exp100	-1.84
Trientine 500μM R08 exp534	-1.83
BAY-598 4μM R05 exp220	-1.77
CCT251545 20μM R07 exp326	-1.71
∆-9-Tetrahydrocannabinol 30μM R08 exp445	1.72
Dimethyl-Sulfoxide 1pc R03 exp120	1.94
Rapamycin 10μM R00 exp30	1.94
Pyridostatin 4μM R05 exp240	1.96
MLN-4924 2μM R00 exp22	2.12
Etoposide 0.1μM R05 exp198	2.44
Golgicide-A 4μM R03 exp122	2.46
Doxorubicin 0.02μM R08 exp478	2.64

Global Fraction of Cell Lines Where Essential: 2/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	1/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	1/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

ubiquitin-like protein conjugating enzyme binding
cyclin binding
ubiquitin conjugating enzyme binding
protein monoubiquitination
protein autoubiquitination
ubiquitin ligase complex
ubiquitin protein ligase activity
protein polyubiquitination
proteasome-mediated ubiquitin-dependent protein catabolic process
proteasomal protein catabolic process
ubiquitin-dependent protein catabolic process
modification-dependent protein catabolic process
modification-dependent macromolecule catabolic process
proteolysis involved in cellular protein catabolic process
cellular protein catabolic process
protein catabolic process
protein ubiquitination
protein modification by small protein conjugation
cellular macromolecule catabolic process
protein modification by small protein conjugation or removal
macromolecule catabolic process
organonitrogen compound catabolic process
proteolysis
organic substance catabolic process
cellular catabolic process