LRRC8E
Gene Information
- Official Symbol: LRRC8E
- Official Name: leucine rich repeat containing 8 VRAC subunit E
- Aliases and Previous Symbols: N/A
- Entrez ID: 80131
- UniProt: Q6NSJ5
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene encodes a member of a small, conserved family of proteins with similar structure, including a string of extracellular leucine-rich repeats. A related protein was shown to be involved in B-cell development. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jun 2012].
- UniProt Summary: Non-essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes. The VRAC channel conducts iodide better than chloride and may also conduct organic osmolytes like taurine. Channel activity requires LRRC8A plus at least one other family member (LRRC8B, LRRC8C, LRRC8D or LRRC8E); channel characteristics depend on the precise subunit composition. {ECO:0000269|PubMed:24790029, ECO:0000269|PubMed:26824658}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 5931
- Expression level (log2 read counts): 1.97
LRRC8E Expression in NALM6 Cells: 1.97
