PRMT3

Entrez Summary: N/A
UniProt Summary: Methylates (mono and asymmetric dimethylation) the guanidino nitrogens of arginyl residues in some proteins.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
CFI-400945 25μM R08 exp469	-1.93
Nicotinamide 2000μM R01 exp50	-1.8
LJH685 5μM R02 exp73	-1.74
CCT251545 20μM R07 exp326	1.7
Pyridostatin 4μM R05 exp240	1.7
proTAME 5μM R04 exp187	1.74
Dexamethasone 0.006 to 0.015μM on day4 R07 exp352	1.83
Beta-Estradiol 0.55μM R07 exp425	1.89
FK-506 30μM R07 exp359	2.09
MK-1775 0.32μM R02 exp75	2.96

Global Fraction of Cell Lines Where Essential: 0/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/25
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/14
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

protein-arginine omega-N asymmetric methyltransferase activity
peptidyl-arginine methylation, to asymmetrical-dimethyl arginine
protein-arginine N-methyltransferase activity
histone-arginine N-methyltransferase activity
peptidyl-arginine omega-N-methylation
peptidyl-arginine N-methylation
histone arginine methylation
peptidyl-arginine methylation
peptidyl-arginine modification
methyltransferase activity
ribosome binding
negative regulation of protein ubiquitination
negative regulation of protein modification by small protein conjugation or removal
histone methylation
protein alkylation
protein methylation
nucleic acid binding
regulation of protein ubiquitination
regulation of protein modification by small protein conjugation or removal
macromolecule methylation
methylation
histone modification
covalent chromatin modification
negative regulation of protein modification process
chromatin organization
peptidyl-amino acid modification
negative regulation of cellular protein metabolic process
chromosome organization
negative regulation of protein metabolic process
regulation of protein modification process