LIG1

Entrez Summary: This gene encodes a member of the ATP-dependent DNA ligase protein family. The encoded protein functions in DNA replication, recombination, and the base excision repair process. Mutations in this gene that lead to DNA ligase I deficiency result in immunodeficiency and increased sensitivity to DNA-damaging agents. Disruption of this gene may also be associated with a variety of cancers. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014].
UniProt Summary: DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 4/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	2/26
breast	1/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	1/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Okazaki fragment processing involved in mitotic DNA replication
DNA replication, Okazaki fragment processing
DNA ligase activity
DNA ligase (ATP) activity
lagging strand elongation
DNA ligation involved in DNA repair
mitotic DNA replication
DNA ligation
V(D)J recombination
DNA strand elongation involved in DNA replication
DNA strand elongation
nucleotide-excision repair, DNA gap filling
mismatch repair
somatic diversification of immune receptors via germline recombination within a single locus
somatic cell DNA recombination
base-excision repair
nuclear DNA replication
cell cycle DNA replication
somatic diversification of immune receptors
transcription-coupled nucleotide-excision repair
DNA biosynthetic process
nucleotide-excision repair
DNA-dependent DNA replication
DNA replication
DNA recombination
cell division
DNA repair
mitotic cell cycle process
immune system development
mitotic cell cycle
intracellular membrane-bounded organelle
DNA metabolic process
cellular response to DNA damage stimulus
cell cycle process
nucleobase-containing compound biosynthetic process
heterocycle biosynthetic process
aromatic compound biosynthetic process
mitochondrion
organic cyclic compound biosynthetic process
cell cycle