NPAP1

Entrez Summary: This gene is located in the Prader-Willi syndrome region on chromosome 15. This gene is biallelically expressed in adult testis and brain but is paternally imprinted in fetal brain. Defects in this gene may be associated with Prader-Willi syndrome. [provided by RefSeq, Aug 2012].
UniProt Summary: May be involved in spermatogenesis.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
CHIR-124 0.04μM R06 exp272	-2.26
Vinorelbine 0.001μM R05 exp249	-2.17
THZ531 0.11 to 0.125μM on day4 R07 exp410	-1.86
Azithromycin 100μM R08 exp452	1.7
Golgicide-A 4μM R03 exp122	1.73
Ibrutinib 10μM R08 exp442	1.92
Clomiphene 4.4μM R02 exp68	1.99
Olaparib 4μM R08 exp512	2.35
Suberoylanilide-Hydroxamic-Acid 0.02μM R01 exp53	2.35
1-Methyl-nicotinamide-chloride 1000μM R03 exp113	2.69

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

nuclear localization sequence binding
structural constituent of nuclear pore
nuclear inner membrane
nuclear pore
protein import into nucleus
import into nucleus
protein import
protein localization to nucleus
nucleocytoplasmic transport
nuclear transport
establishment of protein localization to organelle
spermatogenesis
male gamete generation
gamete generation
protein localization to organelle
molecular function
multicellular organismal reproductive process
sexual reproduction
multicellular organism reproduction
multi-organism reproductive process
intracellular protein transport
reproductive process
reproduction
protein transport
intracellular transport
peptide transport
amide transport
cellular protein localization
cellular macromolecule localization
establishment of protein localization
establishment of localization in cell
nitrogen compound transport