IVNS1ABP

Gene Information

Official Symbol: IVNS1ABP
Official Name: influenza virus NS1A binding protein
Aliases and Previous Symbols: N/A
Entrez ID: 10625
UniProt: Q9Y6Y0
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Plays a role in cell division and in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through Kelch repeats. Protects cells from cell death induced by actin destabilization; Protects neurons from dendritic spines and actin filaments damage induced by the actin-destabilizing cytochalasin B when overexpressed. Activates Erk signaling pathway when overexpressed in cultured cell lines (By similarity). May be a component of the cellular splicing machinery with a role in pre-mRNA splicing; may mediate the inhibition of splicing by NS/influenza virus NS1A protein. Functions as modifier of the AHR/Aryl hydrocarbon receptor pathway increasing the concentration of AHR available to activate transcription. {ECO:0000250, ECO:0000269|PubMed:16582008}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
GSK461364A 0.005μM R03 exp125	-3.19
BI-2536 0.0042μM R03 exp95	-3.13
LY2090314 0.003μM R08 exp500 no dilution day6	-3.13
LY2090314 0.003μM R08 exp499	-3.12
Vemurafenib 6.6μM R02 exp89	-3.1
Vemurafenib 6.6μM R08 exp434	-2.61
MK-1775 0.32μM R02 exp75	-2.55
Q15 2.7μM R02 exp79	-2.23
GSK626616 14μM R08 exp485	-2.17
Ribavirin 10 to 15μM on day4 R04 exp160	-2.17
Temozolomide 200μM R04 exp189	-1.96
BI-D1870 2μM R04 exp162	-1.95
BI-6727 0.0125μM R03 exp97	-1.94
Pyridostatin 4μM R05 exp240	-1.8
BI-D1870 3.15μM R02 exp66	-1.71
GSK461364A 0.1μM R03 exp126	-1.71
UMK57 1μM R01 exp59	-1.71
Etoposide 0.3μM R05 exp199	1.82
Apcin 50 to 100μM on day4 R04 exp176	1.86
SNS-032 15μM R08 exp443	2.29
CCCP 1μM R00 exp11	2.35
Nifuroxazide 5μM R03 exp102	2.57
UM0011500 10μM R05 exp246	2.73

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 19082
Expression level (log2 read counts): 7.65

Expression Distribution

BACK
Kelch 1
BTB

transcription by RNA polymerase III
negative regulation of protein ubiquitination
negative regulation of protein modification by small protein conjugation or removal
spliceosomal complex
negative regulation of intrinsic apoptotic signaling pathway
regulation of intrinsic apoptotic signaling pathway
regulation of protein ubiquitination
transcription factor complex
negative regulation of apoptotic signaling pathway
regulation of protein modification by small protein conjugation or removal
response to virus
cytoskeleton
RNA splicing
regulation of apoptotic signaling pathway
negative regulation of intracellular signal transduction
negative regulation of protein modification process
transcription, DNA-templated
nucleic acid-templated transcription
RNA biosynthetic process
viral process
symbiotic process
interspecies interaction between organisms
RNA processing
negative regulation of apoptotic process
negative regulation of programmed cell death
negative regulation of cell death
negative regulation of cellular protein metabolic process
nucleobase-containing compound biosynthetic process
negative regulation of protein metabolic process
heterocycle biosynthetic process
aromatic compound biosynthetic process
negative regulation of signal transduction
response to other organism
organic cyclic compound biosynthetic process
response to external biotic stimulus
response to biotic stimulus
negative regulation of cell communication
negative regulation of signaling
regulation of apoptotic process
regulation of programmed cell death