IVNS1ABP [The Human Chemical-Genetic Interaction Map Project]

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======= IVNS1ABP =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: IVNS1ABP
  * **<color #00a2e8>Official Name</color>**: influenza virus NS1A binding protein
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10625|10625]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9Y6Y0|Q9Y6Y0]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=IVNS1ABP&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20IVNS1ABP|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/609209|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Plays a role in cell division and in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through Kelch repeats. Protects cells from cell death induced by actin destabilization; Protects neurons from dendritic spines and actin filaments damage induced by the actin-destabilizing cytochalasin B when overexpressed. Activates Erk signaling pathway when overexpressed in cultured cell lines (By similarity). May be a component of the cellular splicing machinery with a role in pre-mRNA splicing; may mediate the inhibition of splicing by NS/influenza virus NS1A protein. Functions as modifier of the AHR/Aryl hydrocarbon receptor pathway increasing the concentration of AHR available to activate transcription. {ECO:0000250, ECO:0000269|PubMed:16582008}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|BACK|
|Kelch 1|
|BTB|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|transcription by RNA polymerase III|
|negative regulation of protein ubiquitination|
|negative regulation of protein modification by small protein conjugation or removal|
|spliceosomal complex|
|negative regulation of intrinsic apoptotic signaling pathway|
|regulation of intrinsic apoptotic signaling pathway|
|regulation of protein ubiquitination|
|transcription factor complex|
|negative regulation of apoptotic signaling pathway|
|regulation of protein modification by small protein conjugation or removal|
|response to virus|
|cytoskeleton|
|RNA splicing|
|regulation of apoptotic signaling pathway|
|negative regulation of intracellular signal transduction|
|negative regulation of protein modification process|
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|RNA biosynthetic process|
|viral process|
|symbiotic process|
|interspecies interaction between organisms|
|RNA processing|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|negative regulation of cell death|
|negative regulation of cellular protein metabolic process|
|nucleobase-containing compound biosynthetic process|
|negative regulation of protein metabolic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|negative regulation of signal transduction|
|response to other organism|
|organic cyclic compound biosynthetic process|
|response to external biotic stimulus|
|response to biotic stimulus|
|negative regulation of cell communication|
|negative regulation of signaling|
|regulation of apoptotic process|
|regulation of programmed cell death|
|negative regulation of response to stimulus|
|cellular nitrogen compound biosynthetic process|
|RNA metabolic process|
|regulation of cell death|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp125|GSK461364A 0.005μM R03 exp125]]|-3.19|
|[[:results:exp95|BI-2536 0.0042μM R03 exp95]]|-3.13|
|[[:results:exp500|LY2090314 0.003μM R08 exp500 no dilution day6]]|-3.13|
|[[:results:exp499|LY2090314 0.003μM R08 exp499]]|-3.12|
|[[:results:exp89|Vemurafenib 6.6μM R02 exp89]]|-3.1|
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|-2.61|
|[[:results:exp75|MK-1775 0.32μM R02 exp75]]|-2.55|
|[[:results:exp79|Q15 2.7μM R02 exp79]]|-2.23|
|[[:results:exp485|GSK626616 14μM R08 exp485]]|-2.17|
|[[:results:exp160|Ribavirin 10 to 15μM on day4 R04 exp160]]|-2.17|
|[[:results:exp189|Temozolomide 200μM R04 exp189]]|-1.96|
|[[:results:exp162|BI-D1870 2μM R04 exp162]]|-1.95|
|[[:results:exp97|BI-6727 0.0125μM R03 exp97]]|-1.94|
|[[:results:exp240|Pyridostatin 4μM R05 exp240]]|-1.8|
|[[:results:exp66|BI-D1870 3.15μM R02 exp66]]|-1.71|
|[[:results:exp126|GSK461364A 0.1μM R03 exp126]]|-1.71|
|[[:results:exp59|UMK57 1μM R01 exp59]]|-1.71|
|[[:results:exp199|Etoposide 0.3μM R05 exp199]]|1.82|
|[[:results:exp176|Apcin 50 to 100μM on day4 R04 exp176]]|1.86|
|[[:results:exp443|SNS-032 15μM R08 exp443]]|2.29|
|[[:results:exp11|CCCP 1μM R00 exp11]]|2.35|
|[[:results:exp102|Nifuroxazide 5μM R03 exp102]]|2.57|
|[[:results:exp246|UM0011500 10μM R05 exp246]]|2.73|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:prps1|PRPS1]]|0.506|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 19082
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.65 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='IVNS1ABP Expression in NALM6 Cells: 7.65'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>