PRPS1 [The Human Chemical-Genetic Interaction Map Project]

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======= PRPS1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PRPS1
  * **<color #00a2e8>Official Name</color>**: phosphoribosyl pyrophosphate synthetase 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5631|5631]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P60891|P60891]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PRPS1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PRPS1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/311850|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes an enzyme that catalyzes the phosphoribosylation of ribose 5-phosphate to 5-phosphoribosyl-1-pyrophosphate, which is necessary for purine metabolism and nucleotide biosynthesis. Defects in this gene are a cause of phosphoribosylpyrophosphate synthetase superactivity, Charcot-Marie-Tooth disease X-linked recessive type 5 and Arts Syndrome. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Pribosyltran|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|urate biosynthetic process|
|hypoxanthine biosynthetic process|
|hypoxanthine metabolic process|
|ribose phosphate diphosphokinase complex|
|ribose phosphate diphosphokinase activity|
|5-phosphoribose 1-diphosphate metabolic process|
|5-phosphoribose 1-diphosphate biosynthetic process|
|purine nucleobase biosynthetic process|
|urate metabolic process|
|nucleobase biosynthetic process|
|purine nucleobase metabolic process|
|ribonucleoside monophosphate biosynthetic process|
|nucleobase metabolic process|
|nucleoside monophosphate biosynthetic process|
|pyrimidine nucleotide biosynthetic process|
|pigment biosynthetic process|
|ribonucleoside monophosphate metabolic process|
|pyrimidine-containing compound biosynthetic process|
|pyrimidine nucleotide metabolic process|
|pigment metabolic process|
|nucleoside monophosphate metabolic process|
|kinase activity|
|pyrimidine-containing compound metabolic process|
|nucleoside metabolic process|
|glycosyl compound metabolic process|
|purine nucleotide biosynthetic process|
|ribose phosphate biosynthetic process|
|purine-containing compound biosynthetic process|
|magnesium ion binding|
|nucleotide biosynthetic process|
|nucleoside phosphate biosynthetic process|
|purine nucleotide metabolic process|
|ribose phosphate metabolic process|
|purine-containing compound metabolic process|
|nucleotide metabolic process|
|nucleoside phosphate metabolic process|
|organophosphate biosynthetic process|
|nucleobase-containing small molecule metabolic process|
|small molecule biosynthetic process|
|carbohydrate derivative biosynthetic process|
|protein homodimerization activity|
|organophosphate metabolic process|
|organic acid metabolic process|
|carbohydrate derivative metabolic process|
|identical protein binding|
|nucleobase-containing compound biosynthetic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|phosphorylation|
|organic cyclic compound biosynthetic process|
|organonitrogen compound biosynthetic process|
|ATP binding|
|cellular nitrogen compound biosynthetic process|
|small molecule metabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp75|MK-1775 0.32μM R02 exp75]]|-3.8|
|[[:results:exp272|CHIR-124 0.04μM R06 exp272]]|-3.21|
|[[:results:exp52|Ribavirin 10μM R01 exp52]]|-3.2|
|[[:results:exp160|Ribavirin 10 to 15μM on day4 R04 exp160]]|-3.11|
|[[:results:exp499|LY2090314 0.003μM R08 exp499]]|-3.08|
|[[:results:exp89|Vemurafenib 6.6μM R02 exp89]]|-2.89|
|[[:results:exp242|Radicicol 0.16μM R05 exp242]]|-2.72|
|[[:results:exp500|LY2090314 0.003μM R08 exp500 no dilution day6]]|-2.7|
|[[:results:exp300|VE-822 0.04μM R06 exp300]]|-2.61|
|[[:results:exp189|Temozolomide 200μM R04 exp189]]|-2.16|
|[[:results:exp319|ABT-702 5μM plus Dimethyloxaloylglycine 11μM R07 exp319]]|-2.11|
|[[:results:exp30|Rapamycin 10μM R00 exp30]]|-2.11|
|[[:results:exp95|BI-2536 0.0042μM R03 exp95]]|-2.04|
|[[:results:exp35|TRAIL 5ng/ml R00 exp35]]|-2.04|
|[[:results:exp169|BH1 1μM R04 exp169]]|-1.98|
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|-1.94|
|[[:results:exp463|Caffeine 2600μM R08 exp463]]|-1.9|
|[[:results:exp71|KU-0063794 3.8μM R02 exp71]]|-1.83|
|[[:results:exp485|GSK626616 14μM R08 exp485]]|-1.78|
|[[:results:exp468|CB-5083 0.4μM R08 exp468]]|-1.76|
|[[:results:exp299|Talazoparib 0.006μM R06 exp299]]|-1.75|
|[[:results:exp59|UMK57 1μM R01 exp59]]|-1.72|
|[[:results:exp294|Nutlin-3A 1.6μM R06 exp294]]|1.7|
|[[:results:exp222|Betulinic acid 10 to 15μM on day4 R05 exp222]]|1.71|
|[[:results:exp116|AICAR 240μM R03 exp116]]|1.72|
|[[:results:exp51|Nifuroxazide 1μM R01 exp51]]|1.73|
|[[:results:exp534|Trientine 500μM R08 exp534]]|1.74|
|[[:results:exp13|Chloramphenicol 20μM R00 exp13]]|1.76|
|[[:results:exp290|LLY-283 2.6μM R06 exp290]]|1.8|
|[[:results:exp67|BVD-523 15μM R02 exp67]]|1.88|
|[[:results:exp65|Mubritinib 0.2μM R02 exp65]]|1.9|
|[[:results:exp519|RS-1 10μM R08 exp519]]|1.94|
|[[:results:exp380|NMS-873 0.07μM R07 exp380]]|2|
|[[:results:exp48|Mubritinib 0.2μM R01 exp48]]|2.15|
|[[:results:exp274|Citral 50μM R06 exp274]]|2.31|
|[[:results:exp143|Phenformin 20μM R03 exp143]]|2.37|
|[[:results:exp191|Hypoxia 5%O2 R04 exp191]]|2.57|
|[[:results:exp248|UM0131023 0.05μM R05 exp248]]|2.58|
|[[:results:exp69|Deguelin 0.05μM R02 exp69]]|2.7|
|[[:results:exp211|AICAR 240μM R05 exp211]]|2.73|
|[[:results:exp241|QNZ 0.01μM R05 exp241]]|2.91|
|[[:results:exp183|IU1-C 25μM R04 exp183]]|3.12|
|[[:results:exp102|Nifuroxazide 5μM R03 exp102]]|4.82|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:i:ivns1abp|IVNS1ABP]]|0.506|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 3/694
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|1/28|
|blood|0/26|
|bone|0/26|
|breast|1/30|
|central nervous system|0/49|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/11|
|fibroblast|0/1|
|gastric|0/14|
|kidney|0/18|
|liver|0/19|
|lung|0/72|
|lymphocyte|0/16|
|ovary|0/25|
|pancreas|0/22|
|peripheral nervous system|0/15|
|plasma cell|0/12|
|prostate|0/1|
|skin|0/20|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/28|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2758
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.05 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PRPS1 Expression in NALM6 Cells: 6.05'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>