PCIF1

Entrez Summary: N/A
UniProt Summary: May play a role in transcription elongation or in coupling transcription to pre-mRNA processing through its association with the phosphorylated C-terminal domain (CTD) of RNAPII largest subunit.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
CoCl2 18μM R07 exp346	-2.31
Rapamycin 2μM plus FK-506 5μM R07 exp308	-2.25
BI-D1870 2μM R04 exp162	-2.22
I-BRD9 4μM R07 exp365	-2.17
IU1-47 25μM R04 exp182	-2.15
Ixabepilone 0.004 to 0.005μM on day4 R04 exp184	-2.05
ABT-702 5μM plus CoCl2 18μM R07 exp320	-1.98
Selumetinib 20μM R02 exp81	-1.79
Epothilone-B 0.0015μM R05 exp231	-1.76
2-Methoxyestradiol 0.55 to 0.75μM on day4 R07 exp311	-1.75
BN82002 4μM R07 exp340	-1.7
Benzoate 20000μM R08 exp456	1.71
Caffeine 2600μM R08 exp463	1.77
R-DABN 8μM R03 exp111	1.78
Clomiphene 4.4μM R02 exp68	1.79
Citral 50μM R06 exp274	1.8
Trimetrexate 0.03μM R08 exp535	1.8
Cerivastatin 0.15μM R05 exp226	1.87
Benzoate 10000μM R08 exp455	1.91
Thapsigargin 0.005μM R07 exp407	1.98
BI-6727 0.04μM R03 exp98	1.99
Tozasertib 0.1μM R07 exp414	1.99
LJH685 50μM R08 exp433	2.03
Resveratrol 16μM R03 exp147	2.03
Citral 75μM R06 exp275	2.04
Nocodazole 0.1μM R03 exp94	2.04
Cannabidiol 20μM R08 exp466	2.12
Quercetin 20μM R08 exp517	2.16
Olaparib 4μM R08 exp512	2.25
Rucaparib 6.5μM R08 exp520	2.35
Hippuristanol 0.12μM R08 exp489 no dilution day6	2.44
Hippuristanol 0.12μM R08 exp488	2.47
Latrunculin-B 10μM R07 exp374	2.65
Cytochalasin-B 5μM R07 exp349	2.71
CB-5083 0.4μM R08 exp468	2.86
GSK626616 14μM R08 exp485	3.48

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Gene	Correlation
PMAIP1	0.416
ZFC3H1	0.415

mRNA (2-O-methyladenosine-N6-)-methyltransferase activity
RNA polymerase II C-terminal domain binding
S-adenosyl-L-methionine binding
mRNA methylation
mRNA modification
intercellular bridge
RNA methylation
negative regulation of phosphatase activity
negative regulation of dephosphorylation
positive regulation of translation
positive regulation of cellular amide metabolic process
microtubule cytoskeleton
RNA modification
regulation of phosphatase activity
regulation of dephosphorylation
macromolecule methylation
methylation
regulation of translation
regulation of cellular amide metabolic process
negative regulation of hydrolase activity
posttranscriptional regulation of gene expression
negative regulation of phosphate metabolic process
negative regulation of phosphorus metabolic process
mRNA metabolic process
negative regulation of catalytic activity
negative regulation of molecular function
regulation of hydrolase activity
positive regulation of cellular protein metabolic process
RNA metabolic process
positive regulation of protein metabolic process
regulation of phosphate metabolic process
regulation of phosphorus metabolic process
positive regulation of macromolecule biosynthetic process
positive regulation of cellular biosynthetic process
positive regulation of gene expression
positive regulation of biosynthetic process