PCIF1 [The Human Chemical-Genetic Interaction Map Project]

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======= PCIF1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PCIF1
  * **<color #00a2e8>Official Name</color>**: PDX1 C-terminal inhibiting factor 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=63935|63935]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9H4Z3|Q9H4Z3]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PCIF1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PCIF1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/618626|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  May play a role in transcription elongation or in coupling transcription to pre-mRNA processing through its association with the phosphorylated C-terminal domain (CTD) of RNAPII largest subunit.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|WW|
|PCIF1 WW|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|mRNA (2-O-methyladenosine-N6-)-methyltransferase activity|
|RNA polymerase II C-terminal domain binding|
|S-adenosyl-L-methionine binding|
|mRNA methylation|
|mRNA modification|
|intercellular bridge|
|RNA methylation|
|negative regulation of phosphatase activity|
|negative regulation of dephosphorylation|
|positive regulation of translation|
|positive regulation of cellular amide metabolic process|
|microtubule cytoskeleton|
|RNA modification|
|regulation of phosphatase activity|
|regulation of dephosphorylation|
|macromolecule methylation|
|methylation|
|regulation of translation|
|regulation of cellular amide metabolic process|
|negative regulation of hydrolase activity|
|posttranscriptional regulation of gene expression|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|mRNA metabolic process|
|negative regulation of catalytic activity|
|negative regulation of molecular function|
|regulation of hydrolase activity|
|positive regulation of cellular protein metabolic process|
|RNA metabolic process|
|positive regulation of protein metabolic process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp346|CoCl2 18μM R07 exp346]]|-2.31|
|[[:results:exp308|Rapamycin 2μM plus FK-506 5μM R07 exp308]]|-2.25|
|[[:results:exp162|BI-D1870 2μM R04 exp162]]|-2.22|
|[[:results:exp365|I-BRD9 4μM R07 exp365]]|-2.17|
|[[:results:exp182|IU1-47 25μM R04 exp182]]|-2.15|
|[[:results:exp184|Ixabepilone 0.004 to 0.005μM on day4 R04 exp184]]|-2.05|
|[[:results:exp320|ABT-702 5μM plus CoCl2 18μM R07 exp320]]|-1.98|
|[[:results:exp81|Selumetinib 20μM R02 exp81]]|-1.79|
|[[:results:exp231|Epothilone-B 0.0015μM R05 exp231]]|-1.76|
|[[:results:exp311|2-Methoxyestradiol 0.55 to 0.75μM  on day4 R07 exp311]]|-1.75|
|[[:results:exp340|BN82002 4μM R07 exp340]]|-1.7|
|[[:results:exp456|Benzoate 20000μM R08 exp456]]|1.71|
|[[:results:exp463|Caffeine 2600μM R08 exp463]]|1.77|
|[[:results:exp111|R-DABN 8μM R03 exp111]]|1.78|
|[[:results:exp68|Clomiphene 4.4μM R02 exp68]]|1.79|
|[[:results:exp274|Citral 50μM R06 exp274]]|1.8|
|[[:results:exp535|Trimetrexate 0.03μM R08 exp535]]|1.8|
|[[:results:exp226|Cerivastatin 0.15μM R05 exp226]]|1.87|
|[[:results:exp455|Benzoate 10000μM R08 exp455]]|1.91|
|[[:results:exp407|Thapsigargin 0.005μM R07 exp407]]|1.98|
|[[:results:exp98|BI-6727 0.04μM R03 exp98]]|1.99|
|[[:results:exp414|Tozasertib 0.1μM R07 exp414]]|1.99|
|[[:results:exp433|LJH685 50μM R08 exp433]]|2.03|
|[[:results:exp147|Resveratrol 16μM R03 exp147]]|2.03|
|[[:results:exp275|Citral 75μM R06 exp275]]|2.04|
|[[:results:exp94|Nocodazole 0.1μM R03 exp94]]|2.04|
|[[:results:exp466|Cannabidiol 20μM R08 exp466]]|2.12|
|[[:results:exp517|Quercetin 20μM R08 exp517]]|2.16|
|[[:results:exp512|Olaparib 4μM R08 exp512]]|2.25|
|[[:results:exp520|Rucaparib 6.5μM R08 exp520]]|2.35|
|[[:results:exp489|Hippuristanol 0.12μM R08 exp489 no dilution day6]]|2.44|
|[[:results:exp488|Hippuristanol 0.12μM R08 exp488]]|2.47|
|[[:results:exp374|Latrunculin-B 10μM R07 exp374]]|2.65|
|[[:results:exp349|Cytochalasin-B 5μM R07 exp349]]|2.71|
|[[:results:exp468|CB-5083 0.4μM R08 exp468]]|2.86|
|[[:results:exp485|GSK626616 14μM R08 exp485]]|3.48|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:pmaip1|PMAIP1]]|0.416|
|[[:human genes:z:zfc3h1|ZFC3H1]]|0.415|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 10593
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.39 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PCIF1 Expression in NALM6 Cells: 5.39'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>