NMT1

Gene Information

Official Symbol: NMT1
Official Name: N-myristoyltransferase 1
Aliases and Previous Symbols: N/A
Entrez ID: 4836
UniProt: P30419
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Adds a myristoyl group to the N-terminal glycine residue of certain cellular and viral proteins. {ECO:0000269|PubMed:25255805, ECO:0000269|PubMed:9353336, ECO:0000269|PubMed:9506952}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Vemurafenib 6.6μM R08 exp434	-2.68
BI-6727 0.04μM R03 exp98	-2.44
MS023 2μM R03 exp134	-2.32
Clomiphene 4.4μM R02 exp68	-2.26
Rotenone 2μM R00 exp33	-2.08
CFI-400945 25μM R08 exp469	-2.06
Phenformin 20μM R03 exp143	-2.06
Nocodazole 0.2μM R00 exp24	-1.99
Vemurafenib 6.6μM R02 exp89	-1.98
Mdivi-1 15μM R05 exp217	-1.95
2-Methoxyestradiol 0.55 to 0.75μM on day4 R07 exp311	-1.76
BI-2536 0.02μM R03 exp96	-1.71
Caffeine 2600μM R08 exp463	-1.7
Dynasore 7μM R08 exp436	1.88
IU1-47 25μM R04 exp182	2.21

Global Fraction of Cell Lines Where Essential: 353/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	14/28
blood	15/28
bone	11/26
breast	16/33
central nervous system	22/56
cervix	2/4
colorectal	12/17
esophagus	9/13
fibroblast	0/1
gastric	11/16
kidney	2/21
liver	11/20
lung	33/75
lymphocyte	11/16
ovary	10/26
pancreas	12/24
peripheral nervous system	6/16
plasma cell	11/15
prostate	0/1
skin	10/24
soft tissue	4/9
thyroid	0/2
upper aerodigestive	17/22
urinary tract	19/29
uterus	1/5

Essentiality in NALM6

Essentiality Rank: 1976
Expression level (log2 read counts): 7.04

Expression Distribution

NMT
NMT C

myristoyltransferase activity
glycylpeptide N-tetradecanoyltransferase activity
N-terminal peptidyl-glycine N-myristoylation
peptidyl-glycine modification
protein myristoylation
N-terminal protein myristoylation
N-terminal protein lipidation
regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
regulation of rhodopsin mediated signaling pathway
positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
N-terminal protein amino acid modification
positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
positive regulation of establishment of protein localization to mitochondrion
extrinsic component of membrane
cellular ketone metabolic process
regulation of mitochondrial membrane permeability
regulation of establishment of protein localization to mitochondrion
regulation of membrane permeability
protein lipidation
lipoprotein biosynthetic process
positive regulation of mitochondrion organization
lipoprotein metabolic process
positive regulation of protein localization to membrane
mitochondrial membrane organization
regulation of G protein-coupled receptor signaling pathway
positive regulation of apoptotic signaling pathway
regulation of mitochondrion organization
protein acylation
regulation of protein localization to membrane
mitochondrial transport
positive regulation of cellular protein localization
in utero embryonic development
regulation of apoptotic signaling pathway
mitochondrion organization
positive regulation of establishment of protein localization
regulation of cellular protein localization
positive regulation of organelle organization
chordate embryonic development
positive regulation of apoptotic process