NRBP1

Entrez Summary: N/A
UniProt Summary: May play a role in subcellular trafficking between the endoplasmic reticulum and Golgi apparatus through interactions with the Rho-type GTPases. Binding to the NS3 protein of dengue virus type 2 appears to subvert this activity into the alteration of the intracellular membrane structure associated with flaviviral replication. {ECO:0000269|PubMed:11956649, ECO:0000269|PubMed:15084397, ECO:0000303|PubMed:11956649}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Nicotine 3000μM R08 exp510	-1.71
39°C R06 exp303	1.7
Geldanamycin 0.01μM R05 exp235	1.7
Docetaxel 0.002μM R01 exp45	1.85
Vincristine 0.0005μM R04 exp190	1.96
Sulforaphane 9μM R08 exp526 no dilution day6	2.03
MLN-4924 0.2μM R00 exp21	2.1
I-BRD9 4μM R07 exp365	2.19
Phenformin 20μM R05 exp212	2.26
Dinaciclib 0.007μM R07 exp355	2.4
3-Bromopyruvate 7μM R04 exp175	2.85

Global Fraction of Cell Lines Where Essential: 413/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	1/1
bile duct	20/28
blood	15/28
bone	13/26
breast	18/33
central nervous system	25/56
cervix	2/4
colorectal	11/17
esophagus	9/13
fibroblast	0/1
gastric	9/16
kidney	8/21
liver	12/20
lung	37/75
lymphocyte	9/16
ovary	10/26
pancreas	19/24
peripheral nervous system	7/16
plasma cell	13/15
prostate	1/1
skin	14/24
soft tissue	5/9
thyroid	1/2
upper aerodigestive	11/22
urinary tract	23/29
uterus	1/5

Expression Distribution

Pkinase
Pkinase Tyr

endomembrane system
cell cortex
transcription initiation from RNA polymerase II promoter
lamellipodium
endoplasmic reticulum to Golgi vesicle-mediated transport
DNA-templated transcription, initiation
protein serine/threonine kinase activity
Golgi vesicle transport
transcription by RNA polymerase II
transcription, DNA-templated
nucleic acid-templated transcription
RNA biosynthetic process
protein homodimerization activity
protein phosphorylation
nucleobase-containing compound biosynthetic process
heterocycle biosynthetic process
aromatic compound biosynthetic process
phosphorylation
organic cyclic compound biosynthetic process
ATP binding
intracellular transport
cellular nitrogen compound biosynthetic process
RNA metabolic process
intracellular signal transduction
cellular macromolecule biosynthetic process
macromolecule biosynthetic process
establishment of localization in cell
vesicle-mediated transport
membrane
gene expression