PCYT1B

Entrez Summary: The protein encoded by this gene belongs to the cytidylyltransferase family. It is involved in the regulation of phosphatidylcholine biosynthesis. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009].
UniProt Summary: Controls phosphatidylcholine synthesis.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/694

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/26
bone	0/26
breast	0/30
central nervous system	0/49
cervix	0/4
colorectal	0/17
esophagus	0/11
fibroblast	0/1
gastric	0/14
kidney	0/18
liver	0/19
lung	0/72
lymphocyte	0/16
ovary	0/25
pancreas	0/22
peripheral nervous system	0/15
plasma cell	0/12
prostate	0/1
skin	0/20
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/28
uterus	0/5

Expression Distribution

Screen	Score
Suberoylanilide-Hydroxamic-Acid 0.02μM R01 exp53	-2.2
BI-2536 0.001μM R01 exp41	-1.72
Resminostat 0.5μM R07 exp393	2.38

choline-phosphate cytidylyltransferase activity
CDP-choline pathway
phosphatidylcholine binding
phosphatidylcholine biosynthetic process
ovarian follicle development
phosphatidylcholine metabolic process
female gonad development
development of primary female sexual characteristics
female sex differentiation
ammonium ion metabolic process
glycerophospholipid biosynthetic process
gonad development
development of primary sexual characteristics
glycerolipid biosynthetic process
phospholipid biosynthetic process
sex differentiation
glycerophospholipid metabolic process
phospholipid metabolic process
glycerolipid metabolic process
reproductive structure development
reproductive system development
organophosphate biosynthetic process
spermatogenesis
male gamete generation
lipid biosynthetic process
developmental process involved in reproduction
gamete generation
multicellular organismal reproductive process
sexual reproduction
multicellular organism reproduction
organophosphate metabolic process
endoplasmic reticulum membrane
cellular lipid metabolic process
multi-organism reproductive process
lipid metabolic process
organonitrogen compound biosynthetic process
reproductive process
reproduction