PCYT1B [The Human Chemical-Genetic Interaction Map Project]

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======= PCYT1B =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PCYT1B
  * **<color #00a2e8>Official Name</color>**: phosphate cytidylyltransferase 1, choline, beta
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9468|9468]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9Y5K3|Q9Y5K3]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PCYT1B&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PCYT1B|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/300948|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene belongs to the cytidylyltransferase family. It is involved in the regulation of phosphatidylcholine biosynthesis. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Controls phosphatidylcholine synthesis.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|CTP transf 2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|choline-phosphate cytidylyltransferase activity|
|CDP-choline pathway|
|phosphatidylcholine binding|
|phosphatidylcholine biosynthetic process|
|ovarian follicle development|
|phosphatidylcholine metabolic process|
|female gonad development|
|development of primary female sexual characteristics|
|female sex differentiation|
|ammonium ion metabolic process|
|glycerophospholipid biosynthetic process|
|gonad development|
|development of primary sexual characteristics|
|glycerolipid biosynthetic process|
|phospholipid biosynthetic process|
|sex differentiation|
|glycerophospholipid metabolic process|
|phospholipid metabolic process|
|glycerolipid metabolic process|
|reproductive structure development|
|reproductive system development|
|organophosphate biosynthetic process|
|spermatogenesis|
|male gamete generation|
|lipid biosynthetic process|
|developmental process involved in reproduction|
|gamete generation|
|multicellular organismal reproductive process|
|sexual reproduction|
|multicellular organism reproduction|
|organophosphate metabolic process|
|endoplasmic reticulum membrane|
|cellular lipid metabolic process|
|multi-organism reproductive process|
|lipid metabolic process|
|organonitrogen compound biosynthetic process|
|reproductive process|
|reproduction|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp53|Suberoylanilide-Hydroxamic-Acid 0.02μM R01 exp53]]|-2.2|
|[[:results:exp41|BI-2536 0.001μM R01 exp41]]|-1.72|
|[[:results:exp393|Resminostat 0.5μM R07 exp393]]|2.38|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/694
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/26|
|bone|0/26|
|breast|0/30|
|central nervous system|0/49|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/11|
|fibroblast|0/1|
|gastric|0/14|
|kidney|0/18|
|liver|0/19|
|lung|0/72|
|lymphocyte|0/16|
|ovary|0/25|
|pancreas|0/22|
|peripheral nervous system|0/15|
|plasma cell|0/12|
|prostate|0/1|
|skin|0/20|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/28|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 16380
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.22 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PCYT1B Expression in NALM6 Cells: 2.22'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>