AKAP3

Entrez Summary: N/A
UniProt Summary: May function as a regulator of both motility- and head- associated functions such as capacitation and the acrosome reaction.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
GSK2606414 1μM R05 exp236	1.87
Resminostat 0.5μM R07 exp393	1.93

sperm fibrous sheath
sperm principal piece
acrosome reaction
protein kinase A binding
blastocyst hatching
hatching
organism emergence from protective structure
acrosomal vesicle
blastocyst development
motile cilium
single fertilization
fertilization
transmembrane receptor protein serine/threonine kinase signaling pathway
in utero embryonic development
chordate embryonic development
embryo development ending in birth or egg hatching
enzyme linked receptor protein signaling pathway
sexual reproduction
embryo development
multi-organism reproductive process
reproductive process
reproduction