DEF8

Entrez Summary: N/A
UniProt Summary: Positively regulates lysosome peripheral distribution and ruffled border formation in osteoclasts. Involved in bone resorption. {ECO:0000250|UniProtKB:Q99J78}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
NN-Diethyl-meta-toluamide 100μM R05 exp237	-1.84
Latrunculin-B 10μM R07 exp374	1.71
Hydroxyurea 100μM R07 exp329	1.74
Rapamycin 2μM R07 exp306	1.77
NMS-873 0.07μM R07 exp380	1.84
Resminostat 0.5μM R07 exp393	2.31

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

positive regulation of ruffle assembly
positive regulation of bone resorption
positive regulation of bone remodeling
regulation of ruffle assembly
positive regulation of tissue remodeling
regulation of bone resorption
lysosome localization
regulation of bone remodeling
regulation of tissue remodeling
positive regulation of plasma membrane bounded cell projection assembly
regulation of plasma membrane bounded cell projection assembly
regulation of cell projection assembly
positive regulation of cell projection organization
positive regulation of cellular component biogenesis
organelle localization
regulation of plasma membrane bounded cell projection organization
regulation of cell projection organization
regulation of cellular component biogenesis
positive regulation of cellular component organization
intracellular signal transduction
positive regulation of multicellular organismal process