GTSE1

Gene Information

Official Symbol: GTSE1
Official Name: G2 and S-phase expressed 1
Aliases and Previous Symbols: N/A
Entrez ID: 51512
UniProt: Q9NYZ3
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: N/A

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Colchicine 0.009μM R05 exp215	-3.07
UMK57 0.6μM R03 exp107	-3
UMK57 1μM R01 exp59	-2.98
Mdivi-1 15μM R05 exp217	-2.86
Quercetin 20μM R08 exp517	-2.86
Demecolcine 0.03μM R05 exp228	-2.62
Taxol 0.004μM R03 exp103	-2.59
Combretastatin A4 0.002 to 0.003μM day4 R04 exp179	-2.53
Epothilone-B 0.0015μM R05 exp231	-2.47
Ixabepilone 0.004 to 0.005μM on day4 R04 exp184	-2.45
Docetaxel 0.002μM R01 exp45	-2.3
HMS-I1 1μM R01 exp46	-2.3
LLY-283 2.6μM R06 exp290	-2.09

Global Fraction of Cell Lines Where Essential: 8/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	1/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	1/16
ovary	0/26
pancreas	0/24
peripheral nervous system	1/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	1/22
urinary tract	1/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 3877
Expression level (log2 read counts): 6.82

Expression Distribution

Gene	Correlation
TACC3	0.582
DLGAP5	0.58
GAK	0.468
ASPM	0.452
GSG2	0.4

positive regulation of protein export from nucleus
regulation of protein export from nucleus
cytoplasmic microtubule
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
intracellular signal transduction involved in G1 DNA damage checkpoint
signal transduction involved in mitotic DNA integrity checkpoint
signal transduction involved in mitotic G1 DNA damage checkpoint
signal transduction involved in mitotic cell cycle checkpoint
signal transduction involved in mitotic DNA damage checkpoint
mitotic G1 DNA damage checkpoint
positive regulation of nucleocytoplasmic transport
mitotic G1/S transition checkpoint
G1 DNA damage checkpoint
signal transduction involved in DNA damage checkpoint
signal transduction involved in DNA integrity checkpoint
signal transduction involved in cell cycle checkpoint
positive regulation of protein localization to nucleus
DNA damage response, signal transduction by p53 class mediator
positive regulation of cell cycle arrest
mitotic DNA damage checkpoint
negative regulation of G1/S transition of mitotic cell cycle
mitotic DNA integrity checkpoint
signal transduction in response to DNA damage
regulation of nucleocytoplasmic transport
negative regulation of cell cycle G1/S phase transition
regulation of cell cycle arrest
regulation of protein localization to nucleus
signal transduction by p53 class mediator
DNA damage checkpoint
DNA integrity checkpoint
regulation of G1/S transition of mitotic cell cycle
mitotic cell cycle checkpoint
positive regulation of intracellular protein transport
regulation of cell cycle G1/S phase transition
protein stabilization
cell cycle checkpoint
positive regulation of intracellular transport
regulation of cell cycle G2/M phase transition
negative regulation of mitotic cell cycle phase transition
regulation of intracellular protein transport