GSG2

Entrez Summary: N/A
UniProt Summary: Serine/threonine-protein kinase that phosphorylates histone H3 at 'Thr-3' (H3T3ph) during mitosis. May act through H3T3ph to both position and modulate activation of AURKB and other components of the chromosomal passenger complex (CPC) at centromeres to ensure proper chromatid cohesion, metaphase alignment and normal progression through the cell cycle. {ECO:0000269|PubMed:11228240, ECO:0000269|PubMed:15681610, ECO:0000269|PubMed:17084365, ECO:0000269|PubMed:20705812, ECO:0000269|PubMed:20929775}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
BML-284 0.09μM R08 exp460	-2.45
Demecolcine 0.03μM R05 exp228	-2.41
Docetaxel 0.002μM R01 exp45	-2.39
Mdivi-1 15μM R05 exp217	-2.3
Colchicine 0.009μM R05 exp215	-2.22
Epothilone-B 0.0015μM R05 exp231	-2.19
Dorsomorphin 5μM R07 exp357	-1.94
HMS-I1 1μM R01 exp46	-1.84
Trametinib 10μM R02 exp83	-1.84
Sulforaphane 9μM R08 exp526 no dilution day6	-1.83
BI-2536 0.0042μM R03 exp95	-1.71
Ixabepilone 0.004 to 0.005μM on day4 R04 exp184	-1.7
Nifuroxazide 1μM R01 exp51	-1.7
HMS-I1 10μM R06 exp256	1.73
Nocodazole 0.1μM R03 exp94	2.99

Global Fraction of Cell Lines Where Essential: 1/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	1/28
bone	0/25
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/14
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

histone H3-T3 phosphorylation involved in chromosome passenger complex localization to kinetochore
chromosome passenger complex localization to kinetochore
histone kinase activity (H3-T3 specific)
histone H3-T3 phosphorylation
histone-threonine phosphorylation
protein localization to kinetochore
mitotic sister chromatid cohesion
protein localization to chromosome, centromeric region
cellular protein-containing complex localization
histone phosphorylation
sister chromatid cohesion
protein localization to chromosome
peptidyl-threonine phosphorylation
peptidyl-threonine modification
mitotic sister chromatid segregation
spindle
chromosome
sister chromatid segregation
mitotic nuclear division
nuclear chromosome segregation
protein kinase activity
protein-containing complex localization
chromosome segregation
nuclear division
organelle fission
protein serine/threonine kinase activity
histone modification
covalent chromatin modification
centrosome
mitotic cell cycle process
mitotic cell cycle
chromatin organization
protein localization to organelle
peptidyl-amino acid modification
protein phosphorylation
cell cycle process
chromosome organization
phosphorylation
cell cycle
ATP binding