GSG2 [The Human Chemical-Genetic Interaction Map Project]

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======= GSG2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: HASPIN
  * **<color #00a2e8>Official Name</color>**: histone H3 associated protein kinase
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=83903|83903]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8TF76|Q8TF76]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=GSG2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20GSG2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/609240|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Serine/threonine-protein kinase that phosphorylates histone H3 at 'Thr-3' (H3T3ph) during mitosis. May act through H3T3ph to both position and modulate activation of AURKB and other components of the chromosomal passenger complex (CPC) at centromeres to ensure proper chromatid cohesion, metaphase alignment and normal progression through the cell cycle. {ECO:0000269|PubMed:11228240, ECO:0000269|PubMed:15681610, ECO:0000269|PubMed:17084365, ECO:0000269|PubMed:20705812, ECO:0000269|PubMed:20929775}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|DUF3635|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|histone H3-T3 phosphorylation involved in chromosome passenger complex localization to kinetochore|
|chromosome passenger complex localization to kinetochore|
|histone kinase activity (H3-T3 specific)|
|histone H3-T3 phosphorylation|
|histone-threonine phosphorylation|
|protein localization to kinetochore|
|mitotic sister chromatid cohesion|
|protein localization to chromosome, centromeric region|
|cellular protein-containing complex localization|
|histone phosphorylation|
|sister chromatid cohesion|
|protein localization to chromosome|
|peptidyl-threonine phosphorylation|
|peptidyl-threonine modification|
|mitotic sister chromatid segregation|
|spindle|
|chromosome|
|sister chromatid segregation|
|mitotic nuclear division|
|nuclear chromosome segregation|
|protein kinase activity|
|protein-containing complex localization|
|chromosome segregation|
|nuclear division|
|organelle fission|
|protein serine/threonine kinase activity|
|histone modification|
|covalent chromatin modification|
|centrosome|
|mitotic cell cycle process|
|mitotic cell cycle|
|chromatin organization|
|protein localization to organelle|
|peptidyl-amino acid modification|
|protein phosphorylation|
|cell cycle process|
|chromosome organization|
|phosphorylation|
|cell cycle|
|ATP binding|
|cellular protein localization|
|cellular macromolecule localization|
|intracellular signal transduction|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp460|BML-284 0.09μM R08 exp460]]|-2.45|
|[[:results:exp228|Demecolcine 0.03μM R05 exp228]]|-2.41|
|[[:results:exp45|Docetaxel 0.002μM R01 exp45]]|-2.39|
|[[:results:exp217|Mdivi-1 15μM R05 exp217]]|-2.3|
|[[:results:exp215|Colchicine 0.009μM R05 exp215]]|-2.22|
|[[:results:exp231|Epothilone-B 0.0015μM R05 exp231]]|-2.19|
|[[:results:exp357|Dorsomorphin 5μM R07 exp357]]|-1.94|
|[[:results:exp46|HMS-I1 1μM R01 exp46]]|-1.84|
|[[:results:exp83|Trametinib 10μM R02 exp83]]|-1.84|
|[[:results:exp526|Sulforaphane 9μM R08 exp526 no dilution day6]]|-1.83|
|[[:results:exp95|BI-2536 0.0042μM R03 exp95]]|-1.71|
|[[:results:exp184|Ixabepilone 0.004 to 0.005μM on day4 R04 exp184]]|-1.7|
|[[:results:exp51|Nifuroxazide 1μM R01 exp51]]|-1.7|
|[[:results:exp256|HMS-I1 10μM R06 exp256]]|1.73|
|[[:results:exp94|Nocodazole 0.1μM R03 exp94]]|2.99|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:a:aspm|ASPM]]|0.535|
|[[:human genes:t:tacc3|TACC3]]|0.531|
|[[:human genes:d:dlgap5|DLGAP5]]|0.525|
|[[:human genes:g:gak|GAK]]|0.472|
|[[:human genes:e:esco2|ESCO2]]|0.447|
|[[:human genes:k:kif15|KIF15]]|0.439|
|[[:human genes:c:cdca2|CDCA2]]|0.421|
|[[:human genes:g:gtse1|GTSE1]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|1/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 5107
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.4 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='GSG2 Expression in NALM6 Cells: 5.4'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>