DYNLT1
Gene Information
- Official Symbol: DYNLT1
- Official Name: dynein light chain Tctex-type 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 6993
- UniProt: P63172
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Binds to transport cargos and is involved in apical cargo transport such as rhodopsin-bearing vesicles in polarized epithelia. May also be a accessory component of axonemal dynein. (Microbial infection) Is involved in intracellular targeting of D-type retrovirus gag polyproteins to the cytoplasmic assembly site. {ECO:0000269|PubMed:18647839}.
Pfam Domains GO Terms
Pfam Domains
| Tctex-1 |
GO Terms
| microtubule-dependent intracellular transport of viral material towards nucleus |
| transport of viral material towards nucleus |
| microtubule-dependent intracellular transport of viral material |
| intracellular protein transport in other organism involved in symbiotic interaction |
| symbiont intracellular protein transport in host |
| intracellular transport of viral protein in host cell |
| secretory vesicle |
| positive regulation of Rac protein signal transduction |
| negative regulation of mitochondrial membrane permeability |
| regulation by virus of viral protein levels in host cell |
| multi-organism cellular localization |
| multi-organism intracellular transport |
| negative regulation of membrane permeability |
| regulation of Rac protein signal transduction |
| cytoplasmic dynein complex |
| axonal growth cone |
| establishment of mitotic spindle orientation |
| establishment of mitotic spindle localization |
| establishment of spindle orientation |
| establishment of spindle localization |
| motor activity |
| spindle localization |
| cytoplasmic microtubule |
| intracellular transport of virus |
| host cell |
| transport of virus |
| positive regulation of Ras protein signal transduction |
| multi-organism transport |
| multi-organism localization |
| positive regulation of small GTPase mediated signal transduction |
| regulation of mitochondrial membrane permeability |
| regulation of membrane permeability |
| viral entry into host cell |
| entry into host cell |
| dendrite development |
| entry into host |
| microtubule cytoskeleton organization involved in mitosis |
| secretory granule lumen |
| establishment of cell polarity |
| spindle |
| ficolin-1-rich granule lumen |
| mitochondrial membrane organization |
| regulation of G protein-coupled receptor signaling pathway |
| interaction with host |
| lamellipodium |
| protein C-terminus binding |
| establishment or maintenance of cell polarity |
| viral life cycle |
| regulation of viral process |
| mitochondrial transport |
| regulation of symbiosis, encompassing mutualism through parasitism |
| regulation of Ras protein signal transduction |
| positive regulation of neuron projection development |
| negative regulation of neurogenesis |
| negative regulation of nervous system development |
| negative regulation of cell development |
| regulation of small GTPase mediated signal transduction |
| establishment of organelle localization |
| positive regulation of neuron differentiation |
| neuronal cell body |
| positive regulation of cell projection organization |
| axon development |
| mitochondrion organization |
| positive regulation of neurogenesis |
| microtubule cytoskeleton organization |
| neuron projection morphogenesis |
| regulation of GTPase activity |
| plasma membrane bounded cell projection morphogenesis |
| neutrophil degranulation |
| cell projection morphogenesis |
| neutrophil activation involved in immune response |
| cell division |
| regulation of neuron projection development |
| neutrophil mediated immunity |
| neutrophil activation |
| granulocyte activation |
| leukocyte degranulation |
| cell part morphogenesis |
| myeloid leukocyte mediated immunity |
| myeloid cell activation involved in immune response |
| positive regulation of nervous system development |
| regulation of cytoskeleton organization |
| positive regulation of cell development |
| organelle localization |
| myeloid leukocyte activation |
| mitotic cell cycle process |
| leukocyte activation involved in immune response |
| cell activation involved in immune response |
| regulation of neuron differentiation |
| neuron projection development |
| microtubule-based process |
| mitotic cell cycle |
| regulation of plasma membrane bounded cell projection organization |
| viral process |
| regulated exocytosis |
| regulation of cell projection organization |
| negative regulation of cell differentiation |
| cell morphogenesis |
| leukocyte mediated immunity |
| regulation of multi-organism process |
| symbiotic process |
| exocytosis |
| neuron development |
| regulation of neurogenesis |
| interspecies interaction between organisms |
| cellular component morphogenesis |
| membrane organization |
| regulation of nervous system development |
| leukocyte activation |
| regulation of cell development |
| negative regulation of developmental process |
| positive regulation of cell differentiation |
| Golgi apparatus |
| intracellular protein transport |
| negative regulation of cell death |
| cell cycle process |
| secretion by cell |
| neuron differentiation |
| positive regulation of intracellular signal transduction |
| export from cell |
| identical protein binding |
| cell activation |
| immune effector process |
| cytoskeleton organization |
| chemical homeostasis |
| plasma membrane bounded cell projection organization |
| secretion |
| cell projection organization |
| negative regulation of multicellular organismal process |
| positive regulation of cellular component organization |
| mitochondrion |
| regulation of hydrolase activity |
| regulation of organelle organization |
| cell cycle |
| positive regulation of developmental process |
| protein transport |
| intracellular transport |
| generation of neurons |
| peptide transport |
| amide transport |
| cellular protein localization |
| cellular macromolecule localization |
| establishment of protein localization |
| neurogenesis |
| homeostatic process |
| cell development |
| positive regulation of signal transduction |
| regulation of cell death |
| positive regulation of multicellular organismal process |
| regulation of cell differentiation |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of intracellular signal transduction |
| establishment of localization in cell |
| nitrogen compound transport |
| immune response |
| extracellular region |
| vesicle-mediated transport |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| BI-6727 0.0125μM R03 exp97 | -2.87 |
| Epothilone-B 0.0015μM R05 exp231 | -2.71 |
| BI-2536 0.0042μM R03 exp95 | -2.26 |
| GSK461364A 0.005μM R03 exp125 | -2.03 |
| 5-Fluorouracil 20μM R00 exp2 | -1.99 |
| Trichostatin-A 0.06μM R07 exp415 | -1.97 |
| LY2090314 0.003μM R08 exp499 | -1.88 |
| Rucaparib 6.5μM R08 exp520 | -1.82 |
| UMK57 0.6μM R03 exp107 | -1.76 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 12022
- Expression level (log2 read counts): 4.65
Expression Distribution
DYNLT1 Expression in NALM6 Cells: 4.65
