COMMD5 [The Human Chemical-Genetic Interaction Map Project]

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======= COMMD5 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: COMMD5
  * **<color #00a2e8>Official Name</color>**: COMM domain containing 5
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=28991|28991]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9GZQ3|Q9GZQ3]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=COMMD5&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20COMMD5|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/608216|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes (PubMed:21778237). Negatively regulates cell proliferation. Negatively regulates cell cycle G2/M phase transition probably by transactivating p21/CDKN1A through the p53/TP53-independent signaling pathway. Involved in kidney proximal tubule morphogenesis (By similarity). Down-regulates activation of NF-kappa-B (PubMed:15799966). {ECO:0000250|UniProtKB:Q9ERR2, ECO:0000269|PubMed:15799966, ECO:0000305|PubMed:21778237}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='default' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|HCaRG|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
No GO term information is available for this gene.
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp321|ABT-702 5μM plus Deferoxamine 11μM R07 exp321]]|-2.89|
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|-2.83|
|[[:results:exp79|Q15 2.7μM R02 exp79]]|-2.76|
|[[:results:exp68|Clomiphene 4.4μM R02 exp68]]|-2.57|
|[[:results:exp483|FTY720 3μM R08 exp483]]|-2.55|
|[[:results:exp400|Senexin-A 25μM R07 exp400]]|-2.55|
|[[:results:exp222|Betulinic acid 10 to 15μM on day4 R05 exp222]]|-2.3|
|[[:results:exp454|Bafilomycin-A1 0.009μM R08 exp454]]|-2.27|
|[[:results:exp89|Vemurafenib 6.6μM R02 exp89]]|-2.27|
|[[:results:exp227|Cryptotanshinone 12μM R05 exp227]]|-2.23|
|[[:results:exp490|Hydroxychloroquine 30μM R08 exp490]]|-2.23|
|[[:results:exp164|Q15 1 to 2μM on day4 R04 exp164]]|-2.01|
|[[:results:exp470|Chloroquine 32μM R08 exp470]]|-1.98|
|[[:results:exp538|ZLN024 50μM R08 exp538]]|-1.86|
|[[:results:exp433|LJH685 50μM R08 exp433]]|-1.82|
|[[:results:exp530|Thioridazine 5μM R08 exp530]]|-1.78|
|[[:results:exp233|EPZ-5676 30μM R05 exp233]]|-1.77|
|[[:results:exp53|Suberoylanilide-Hydroxamic-Acid 0.02μM R01 exp53]]|-1.76|
|[[:results:exp183|IU1-C 25μM R04 exp183]]|-1.73|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:c:ccdc22|CCDC22]]|0.688|
|[[:human genes:a:arpc2|ARPC2]]|0.672|
|[[:human genes:a:arpc4|ARPC4]]|0.646|
|[[:human genes:a:actr3|ACTR3]]|0.618|
|[[:human genes:c:commd3|COMMD3]]|0.613|
|[[:human genes:c:commd2|COMMD2]]|0.594|
|[[:human genes:v:vps29|VPS29]]|0.56|
|[[:human genes:c:commd7|COMMD7]]|0.544|
|[[:human genes:c:commd9|COMMD9]]|0.536|
|[[:human genes:c:commd8|COMMD8]]|0.51|
|[[:human genes:c:commd10|COMMD10]]|0.5|
|[[:human genes:k:kiaa0196|KIAA0196]]|0.499|
|[[:human genes:a:actr2|ACTR2]]|0.491|
|[[:human genes:r:rab7a|RAB7A]]|0.471|
|[[:human genes:c:ccdc53|CCDC53]]|0.46|
|[[:human genes:l:lipa|LIPA]]|0.444|
|[[:human genes:l:lzic|LZIC]]|0.438|
|[[:human genes:c:c16orf62|C16orf62]]|0.43|
|[[:human genes:c:chka|CHKA]]|0.426|
|[[:human genes:v:vps35|VPS35]]|0.424|
|[[:human genes:c:commd4|COMMD4]]|0.424|
|[[:human genes:m:mtmr9|MTMR9]]|0.412|
|[[:human genes:k:kiaa1033|KIAA1033]]|0.41|
|[[:human genes:u:usp32|USP32]]|0.403|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|1/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 8264
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.9 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='COMMD5 Expression in NALM6 Cells: 1.9'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>