LIPA

Entrez Summary: This gene encodes lipase A, the lysosomal acid lipase (also known as cholesterol ester hydrolase). This enzyme functions in the lysosome to catalyze the hydrolysis of cholesteryl esters and triglycerides. Mutations in this gene can result in Wolman disease and cholesteryl ester storage disease. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2014].
UniProt Summary: Crucial for the intracellular hydrolysis of cholesteryl esters and triglycerides that have been internalized via receptor- mediated endocytosis of lipoprotein particles. Important in mediating the effect of LDL (low density lipoprotein) uptake on suppression of hydroxymethylglutaryl-CoA reductase and activation of endogenous cellular cholesteryl ester formation.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Clomiphene 4.4μM R02 exp68	-2.79
Betulinic acid 10 to 15μM on day4 R05 exp222	-2.33
UM0011500 5μM R05 exp245	-2.25
Suberoylanilide-Hydroxamic-Acid 0.02μM R01 exp53	-1.85
Cerivastatin 0.15μM R05 exp226	1.77
Artemisinin 50μM R08 exp450	1.82
JQ1 0.8μM R08 exp435	2.15

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Gene	Correlation
COMMD5	0.444
VPS41	0.401

sterol esterase activity
lipase activity
low-density lipoprotein particle clearance
homeostasis of number of cells within a tissue
plasma lipoprotein particle clearance
regulation of plasma lipoprotein particle levels
lysosomal lumen
tissue remodeling
fibrillar center
sterol metabolic process
cytokine production
lung development
respiratory tube development
tissue homeostasis
respiratory system development
homeostasis of number of cells
lysosome
steroid metabolic process
lipid catabolic process
multicellular organismal homeostasis
anatomical structure homeostasis
organic hydroxy compound metabolic process
inflammatory response
cell population proliferation
intracellular membrane-bounded organelle
cell morphogenesis
cellular component morphogenesis
tube development
cellular lipid metabolic process
lipid metabolic process
defense response
homeostatic process
organic substance catabolic process