VKORC1L1 [The Human Chemical-Genetic Interaction Map Project]

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======= VKORC1L1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: VKORC1L1
  * **<color #00a2e8>Official Name</color>**: vitamin K epoxide reductase complex subunit 1 like 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=154807|154807]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8N0U8|Q8N0U8]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=VKORC1L1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20VKORC1L1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/608838|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes an enzyme important in the vitamin K cycle, which is involved in the carboxylation of glutamate residues present in vitamin K-dependent proteins. The encoded enzyme catalyzes the de-epoxidation of vitamin K 2,3-epoxide. Oxidative stress may upregulate expression of this gene and the encoded protein may protect cells and membrane proteins form oxidative damage. This gene and a related gene (Gene ID: 79001) may have arisen by gene duplication of an ancestral gene. [provided by RefSeq, Oct 2016]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Involved in vitamin K metabolism. Can reduce inactive vitamin K 2,3-epoxide to active vitamin K (in vitro), and may contribute to vitamin K-mediated protection against oxidative stress. Plays a role in vitamin K-dependent gamma-carboxylation of Glu residues in target proteins. {ECO:0000269|PubMed:21367861, ECO:0000269|PubMed:23928358, ECO:0000269|PubMed:24532791}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|VKOR|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|vitamin-K-epoxide reductase (warfarin-sensitive) activity|
|protein carboxylation|
|peptidyl-glutamic acid carboxylation|
|vitamin K metabolic process|
|quinone binding|
|peptidyl-glutamic acid modification|
|fat-soluble vitamin metabolic process|
|vitamin metabolic process|
|cellular response to oxidative stress|
|response to oxidative stress|
|peptidyl-amino acid modification|
|endoplasmic reticulum membrane|
|oxidation-reduction process|
|endoplasmic reticulum|
|cellular response to stress|
|small molecule metabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp169|BH1 1μM R04 exp169]]|-4.88|
|[[:results:exp164|Q15 1 to 2μM on day4 R04 exp164]]|-4.66|
|[[:results:exp89|Vemurafenib 6.6μM R02 exp89]]|-4.52|
|[[:results:exp68|Clomiphene 4.4μM R02 exp68]]|-4.31|
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|-4.13|
|[[:results:exp79|Q15 2.7μM R02 exp79]]|-4.08|
|[[:results:exp90|WYE-354 6μM R02 exp90]]|-3.57|
|[[:results:exp530|Thioridazine 5μM R08 exp530]]|-3.13|
|[[:results:exp454|Bafilomycin-A1 0.009μM R08 exp454]]|-3.11|
|[[:results:exp436|Dynasore 7μM R08 exp436]]|-2.93|
|[[:results:exp122|Golgicide-A 4μM R03 exp122]]|-2.75|
|[[:results:exp180|Dynasore 10μM R04 exp180]]|-2.73|
|[[:results:exp469|CFI-400945 25μM R08 exp469]]|-2.63|
|[[:results:exp344|Chlorpromazine 10μM R07 exp344]]|-2.55|
|[[:results:exp461|BS-181 20μM R08 exp461]]|-2.26|
|[[:results:exp483|FTY720 3μM R08 exp483]]|-2.13|
|[[:results:exp510|Nicotine 3000μM R08 exp510]]|-2.13|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|-2.07|
|[[:results:exp507|Monensin 0.3μM R08 exp507]]|-2.06|
|[[:results:exp498|Lead acetate 2000μM R08 exp498 no dilution day6]]|-1.89|
|[[:results:exp470|Chloroquine 32μM R08 exp470]]|-1.88|
|[[:results:exp282|Fluvastatin 2.2μM R06 exp282]]|-1.88|
|[[:results:exp77|Prochlorperazine 5.2μM R02 exp77]]|-1.81|
|[[:results:exp419|Tunicamycin 0.04 to 0.075μM  on day4 R07 exp419]]|-1.75|
|[[:results:exp422|Wiskostatin 3μM R07 exp422]]|-1.73|
|[[:results:exp515|PU-H71 1μM R08 exp515]]|-1.72|
|[[:results:exp11|CCCP 1μM R00 exp11]]|1.74|
|[[:results:exp317|Geldanamycin 0.015 to 0.05μM on day4 R07 exp317]]|1.74|
|[[:results:exp342|Calcium Ionophore 0.4μM R07 exp342]]|2.06|
|[[:results:exp61|YM155 0.0002μM R01 exp61]]|2.13|
|[[:results:exp21|MLN-4924 0.2μM R00 exp21]]|2.48|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:c:chka|CHKA]]|0.594|
|[[:human genes:p:pcyt1a|PCYT1A]]|0.56|
|[[:human genes:m:mmd|MMD]]|0.495|
|[[:human genes:m:mbtps1|MBTPS1]]|0.48|
|[[:human genes:a:apba3|APBA3]]|0.476|
|[[:human genes:f:flvcr1|FLVCR1]]|0.476|
|[[:human genes:g:gpr107|GPR107]]|0.474|
|[[:human genes:s:sgms1|SGMS1]]|0.469|
|[[:human genes:s:scap|SCAP]]|0.467|
|[[:human genes:a:actr2|ACTR2]]|0.463|
|[[:human genes:c:cog7|COG7]]|0.461|
|[[:human genes:u:unc50|UNC50]]|0.459|
|[[:human genes:c:cog5|COG5]]|0.433|
|[[:human genes:a:arpc4|ARPC4]]|0.43|
|[[:human genes:t:tbc1d23|TBC1D23]]|0.429|
|[[:human genes:c:cnep1r1|CNEP1R1]]|0.428|
|[[:human genes:g:gpr89a|GPR89A]]|0.427|
|[[:human genes:s:sptlc1|SPTLC1]]|0.425|
|[[:human genes:s:sptlc2|SPTLC2]]|0.424|
|[[:human genes:a:acsl4|ACSL4]]|0.422|
|[[:human genes:d:dmxl1|DMXL1]]|0.42|
|[[:human genes:g:gpr89b|GPR89B]]|0.415|
|[[:human genes:c:col4a3bp|COL4A3BP]]|0.408|
|[[:human genes:u:usp32|USP32]]|0.404|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 18545
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.61 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='VKORC1L1 Expression in NALM6 Cells: 6.61'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>