SYVN1

Gene Information

Official Symbol: SYVN1
Official Name: synoviolin 1
Aliases and Previous Symbols: N/A
Entrez ID: 84447
UniProt: Q86TM6
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes a protein involved in endoplasmic reticulum (ER)-associated degradation. The encoded protein removes unfolded proteins, accumulated during ER stress, by retrograde transport to the cytosol from the ER. This protein also uses the ubiquitin-proteasome system for additional degradation of unfolded proteins. Sequence analysis identified two transcript variants that encode different isoforms. [provided by RefSeq, May 2011].
UniProt Summary: Acts as an E3 ubiquitin-protein ligase which accepts ubiquitin specifically from endoplasmic reticulum-associated UBC7 E2 ligase and transfers it to substrates, promoting their degradation (PubMed:12459480, PubMed:12646171, PubMed:12975321, PubMed:14593114, PubMed:16289116, PubMed:16847254, PubMed:17059562, PubMed:17141218, PubMed:17170702, PubMed:22607976, PubMed:26471130). Component of the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation (ERAD) involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins (PubMed:12459480, PubMed:12646171, PubMed:12975321, PubMed:14593114, PubMed:16289116, PubMed:16847254, PubMed:17059562, PubMed:17141218, PubMed:17170702, PubMed:22607976, PubMed:26471130). Also promotes the degradation of normal but naturally short-lived proteins such as SGK. Protects cells from ER stress-induced apoptosis. Protects neurons from apoptosis induced by polyglutamine-expanded huntingtin (HTT) or unfolded GPR37 by promoting their degradation (PubMed:17141218). Sequesters p53/TP53 in the cytoplasm and promotes its degradation, thereby negatively regulating its biological function in transcription, cell cycle regulation and apoptosis (PubMed:17170702). Mediates the ubiquitination and subsequent degradation of cytoplasmic NFE2L1 (By similarity). {ECO:0000250|UniProtKB:Q9DBY1, ECO:0000269|PubMed:12459480, ECO:0000269|PubMed:12646171, ECO:0000269|PubMed:12975321, ECO:0000269|PubMed:14593114, ECO:0000269|PubMed:16289116, ECO:0000269|PubMed:16847254, ECO:0000269|PubMed:17059562, ECO:0000269|PubMed:17141218, ECO:0000269|PubMed:17170702, ECO:0000269|PubMed:22607976, ECO:0000269|PubMed:26471130}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
ABT-702 5μM plus CoCl2 18μM R07 exp320	-3.18
MK2206 4μM R08 exp504	-2.1
Nocodazole 0.1μM R03 exp94	-2.04
Oligomycin-A 20μM R00 exp26	-1.94
JQ1 0.8μM R08 exp435	-1.93
Colchicine 0.009μM R05 exp215	-1.75
CoCl2 18μM R07 exp346	-1.72
GSK461364A 0.1μM R03 exp126	-1.71
Dexamethasone 0.006 to 0.015μM on day4 R07 exp352	1.73
FBS-Wisent 0.1 R07 exp426	1.77
VHL-ligand-1 20μM R07 exp421	1.78
BI-6727 0.001μM R01 exp42	1.79
BS-181 20μM R08 exp461	1.79
GW501516 25μM R06 exp285	1.81
GSK461364A 0.005μM R03 exp125	1.93
S-trityl-L-cysteine 0.5μM R05 exp243	1.93
Ethambutol 25μM R08 exp481	1.95
Tozasertib 0.1μM R07 exp414	1.98
Taxol 0.004μM R03 exp103	2.06
BI-2536 0.0042μM R03 exp95	2.12
GSK591 2.6μM R03 exp128	2.12
OICR-9429 10μM R03 exp142	2.21
BH1 1μM R04 exp169	3.07

Global Fraction of Cell Lines Where Essential: 11/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	1/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	1/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	6/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 504
Expression level (log2 read counts): 8.38

Expression Distribution

zf-C3HC4
zf-rbx1

Hrd1p ubiquitin ligase complex
Hrd1p ubiquitin ligase ERAD-L complex
Derlin-1 retrotranslocation complex
endoplasmic reticulum mannose trimming
ubiquitin-specific protease binding
endoplasmic reticulum to cytosol transport
retrograde protein transport, ER to cytosol
negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
protein demannosylation
protein alpha-1,2-demannosylation
endoplasmic reticulum quality control compartment
protein exit from endoplasmic reticulum
smooth endoplasmic reticulum
protein deglycosylation
regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
protein N-linked glycosylation via asparagine
peptidyl-asparagine modification
negative regulation of response to endoplasmic reticulum stress
protein K48-linked ubiquitination
IRE1-mediated unfolded protein response
ubiquitin-dependent ERAD pathway
protein N-linked glycosylation
ATPase binding
regulation of response to endoplasmic reticulum stress
ERAD pathway
negative regulation of intrinsic apoptotic signaling pathway
chaperone binding
endoplasmic reticulum unfolded protein response
integral component of endoplasmic reticulum membrane
cellular response to unfolded protein
unfolded protein binding
cellular response to topologically incorrect protein
regulation of intrinsic apoptotic signaling pathway
response to unfolded protein
protein stabilization
response to topologically incorrect protein
ubiquitin protein ligase activity
negative regulation of apoptotic signaling pathway
protein glycosylation
response to endoplasmic reticulum stress