DUSP16

Gene Information

Official Symbol: DUSP16
Official Name: dual specificity phosphatase 16
Aliases and Previous Symbols: N/A
Entrez ID: 80824
UniProt: Q9BY84
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes a mitogen-activated protein kinase phosphatase that is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. The encoded protein specifically regulates the c-Jun amino-terminal kinase (JNK) and extracellular signal-regulated kinase (ERK) pathways.[provided by RefSeq, May 2010].
UniProt Summary: Dual specificity protein phosphatase involved in the inactivation of MAP kinases. Dephosphorylates MAPK10 bound to ARRB2. {ECO:0000269|PubMed:11489891, ECO:0000269|PubMed:15888437}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
JQ1 0.01μM R03 exp130	-2.46
Aminopterin 0.005μM R07 exp335	-2.03
RO-3307 4.7μM R02 exp80	-1.97
QNZ 0.01μM R08 exp439	-1.91
Tanespimycin 14μM R08 exp527	-1.91
Lenalidomide 20μM R07 exp375	-1.78
UM0011500 10μM R05 exp246	-1.75
BI-D1870 2μM R04 exp162	1.7
Arsenic trioxide 60μM R08 exp449	1.78
Cholesterol 0.003 to 0.006 to 0.1μM on day2 then day6 R08 exp471	1.83
Erlotinib 10μM R05 exp216	1.98
BH1 1μM R04 exp169	2.11

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 18253
Expression level (log2 read counts): 3.74

Expression Distribution

DSPc
Rhodanese

MAPK phosphatase export from nucleus
MAPK phosphatase export from nucleus, leptomycin B sensitive
MAPK export from nucleus
MAP kinase tyrosine/serine/threonine phosphatase activity
inactivation of MAPK activity
phosphoprotein phosphatase activity
protein tyrosine/serine/threonine phosphatase activity
phosphatase activity
negative regulation of MAP kinase activity
protein tyrosine phosphatase activity
peptidyl-tyrosine dephosphorylation
negative regulation of protein serine/threonine kinase activity
protein export from nucleus
nuclear export
negative regulation of MAPK cascade
protein dephosphorylation
negative regulation of protein kinase activity
negative regulation of kinase activity
cytoplasmic vesicle
nucleocytoplasmic transport
nuclear transport
negative regulation of transferase activity
dephosphorylation
regulation of MAP kinase activity
negative regulation of protein phosphorylation
negative regulation of phosphorylation
negative regulation of intracellular signal transduction
regulation of protein serine/threonine kinase activity
negative regulation of phosphate metabolic process
negative regulation of phosphorus metabolic process
negative regulation of protein modification process
regulation of MAPK cascade
negative regulation of catalytic activity
regulation of protein kinase activity
regulation of kinase activity
regulation of transferase activity
intracellular protein transport
negative regulation of cellular protein metabolic process
negative regulation of protein metabolic process
negative regulation of molecular function