BH1 1μM R04 exp169 [The Human Chemical-Genetic Interaction Map Project]

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====== BH1 1μM R04 exp169 ======
==== Mechanism of Action ====
Unknown
  * **<color #00a2e8>Class / Subclass 1:</color>** Uncharacterized Mechanism / Chemical Screen Hit




==== Technical Notes ====
<accordion collapsed='true'>
<panel title='Compound References' collapsed='true'>
    * **<color #00a2e8>PubChem Name:</color>** %%4-Amino-N-[4-[5-[(4-aminobenzoyl)amino]-4-chloro-1H-benzimidazol-2-yl]-2-chlorophenyl]benzamide%%
    * **<color #00a2e8>Synonyms:</color>** N/A
    * **<color #00a2e8>CAS #:</color>** 331424-77-2
    * **<color #00a2e8>PubChem CID:</color>** [[https://pubchem.ncbi.nlm.nih.gov/compound/4225810|4225810]]
    * **<color #00a2e8>IUPAC:</color>** %%4-amino-N-[4-[5-[(4-aminobenzoyl)amino]-4-chloro-1H-benzimidazol-2-yl]-2-chlorophenyl]benzamide%%
    * **<color #00a2e8>INCHI Name:</color>** InChI=1S/C27H20Cl2N6O2/c28-19-13-16(5-10-20(19)33-26(36)14-1-6-17(30)7-2-14)25-32-22-12-11-21(23(29)24(22)35-25)34-27(37)15-3-8-18(31)9-4-15/h1-13H,30-31H2,(H,32,35)(H,33,36)(H,34,37)
    * **<color #00a2e8>INCHI Key:</color>** TYLWSXFXCJNMCK-UHFFFAOYSA-N
    * **<color #00a2e8>Molecular Weight:</color>** 531.4
    * **<color #00a2e8>Canonical SMILES:</color>** C1=CC(=CC=C1C(=O)NC2=C(C=C(C=C2)C3=NC4=C(N3)C=CC(=C4Cl)NC(=O)C5=CC=C(C=C5)N)Cl)N
    * **<color #00a2e8>Isomeric SMILES:</color>** N/A
    * **<color #00a2e8>Molecular Formula:</color>** C27H20Cl2N6O2
{{:chemogenomics:structures:chem-0073.svg?nolink}}
</panel>


<panel title='Compound Supplier' collapsed='true'>
    * **<color #00a2e8>Supplier Name:</color>** AMB Inter
    * **<color #00a2e8>Catalog #:</color>** Amb6869981
    * **<color #00a2e8>Lot #:</color>** N/A
</panel>


<panel title='Compound Characterization' collapsed='true'>
    * **<color #00a2e8>HRMS (ESI-TOF) m/z:</color>** (M+H)+ Calcd for C27H20Cl2N6O2 531.10976; found 531.11054
</panel>


<panel title='Dose Response Curve' collapsed='true'>
    * **<color #00a2e8>Platform ID:</color>** BH1
    * **<color #00a2e8>Min:</color>** -2.2884; **<color #00a2e8>Max:</color>** 92.0020
{{:chemogenomics:dose_response:dr_73.png?nolink&500 |}}
\\ 
\\ 
\\ 
\\ 
|< 300px 100px 200px >|
^ IC   ^ Concentration (µM) ^
| IC10  |N/A    |
| IC20  |3.2607    |
| IC30  |3.9287    |
| IC40  |4.5772    |
| IC50  |5.2661    |
| IC60  |N/A    |
| IC70  |N/A    |
| IC80  |N/A    |
| IC90  |N/A    |
\\ 
</panel>
</accordion>
==== Screen Summary ====
    * **<color #00a2e8>Round</color>**: 04
    * **<color #00a2e8>Dose</color>**: 1µM
    * **<color #00a2e8>Days of incubation</color>**: 8
    * **<color #00a2e8>Doublings</color>**: 6.7
    * **<color #00a2e8>Numbers of reads</color>**: 18813435


==== Screen Results ====


^Sensitive/Resistant hits (FDR<0.05)^CRANKS^Score Plot^Top 30 Genes^Screen Similarity^Top 30 Sensitive GO terms^Top 30 Resistant GO terms^
|54/0|<color #e85500>[[https://files.tyerslab.com/files/public/chemogenomics/cranks/BH1_1uM_Round-4_exp169.txt|Scores]]</color>|<button type="primary" size="sm" modal="ScorePlot">View</button>|<button type="primary" size="sm" modal="modal_hits">View</button>|<button type="primary" size="sm" modal="modal_screen_similarity">View</button>|<button type="primary" size="sm" modal="modal_go_sensitive">View</button>|<button type="primary" size="sm" modal="modal_go_resistant">View</button>|
<modal id='ScorePlot' size='lg' title='BH1 1μM R04 exp169'>
{{:chemogenomics:cranks_plots:exp169.png?nolink}}
</modal>


<modal id="modal_hits" size="sm" title="Top 30 S/R Genes">
^Gene^CRANKS Score^FDR^
|[[:human_genes:V:VKORC1L1|VKORC1L1]]|-4.88|<0.01|
|[[:human_genes:K:KDSR|KDSR]]|-4.68|<0.01|
|[[:human_genes:S:SCAP|SCAP]]|-4.29|<0.01|
|[[:human_genes:S:SPTLC1|SPTLC1]]|-4.18|<0.01|
|[[:human_genes:G:GPR107|GPR107]]|-4.04|<0.01|
|[[:human_genes:S:SGMS1|SGMS1]]|-4.01|<0.01|
|[[:human_genes:A:ARL1|ARL1]]|-3.97|<0.01|
|[[:human_genes:C:COL4A3BP|COL4A3BP]]|-3.91|<0.01|
|[[:human_genes:C:CHKA|CHKA]]|-3.74|<0.01|
|[[:human_genes:C:CTDNEP1|CTDNEP1]]|-3.58|<0.01|
|[[:human_genes:C:COG5|COG5]]|-3.45|<0.01|
|[[:human_genes:L:LDLR|LDLR]]|-3.44|<0.01|
|[[:human_genes:D:DYM|DYM]]|-3.42|<0.01|
|[[:human_genes:L:LDLRAP1|LDLRAP1]]|-3.29|<0.01|
|[[:human_genes:A:ATP6V0A2|ATP6V0A2]]|-3.25|<0.01|
|[[:human_genes:U:UNC50|UNC50]]|-3.23|<0.01|
|[[:human_genes:A:ATP6V1G1|ATP6V1G1]]|-3.11|<0.01|
|[[:human_genes:C:COG7|COG7]]|-3.08|<0.01|
|[[:human_genes:T:TBC1D23|TBC1D23]]|-3.05|<0.01|
|[[:human_genes:A:APBA3|APBA3]]|-3.02|<0.01|
|[[:human_genes:R:RAB7A|RAB7A]]|-3.01|<0.01|
|[[:human_genes:C:CDK2|CDK2]]|-2.99|<0.01|
|[[:human_genes:M:MBTPS1|MBTPS1]]|-2.98|<0.01|
|[[:human_genes:G:GCLM|GCLM]]|-2.98|<0.01|
|[[:human_genes:R:RALGAPB|RALGAPB]]|-2.90|<0.01|
|[[:human_genes:S:SPTLC2|SPTLC2]]|-2.85|<0.01|
|[[:human_genes:O:OSBP|OSBP]]|-2.84|<0.01|
|[[:human_genes:C:COG6|COG6]]|-2.82|<0.01|
|[[:human_genes:N:NCOR1|NCOR1]]|-2.77|<0.01|
|[[:human_genes:K:KIAA1432|KIAA1432]]|-2.76|<0.01|
|[[:human_genes:S:SEC31A|SEC31A]]|1.97|0.54|
|[[:human_genes:A:ATP6AP1|ATP6AP1]]|1.99|0.61|
|[[:human_genes:N:NOP14|NOP14]]|1.99|0.54|
|[[:human_genes:Z:ZBED2|ZBED2]]|1.99|0.63|
|[[:human_genes:N:NUP188|NUP188]]|2.01|0.59|
|[[:human_genes:B:BCL11A|BCL11A]]|2.02|0.54|
|[[:human_genes:S:SEC13|SEC13]]|2.04|0.59|
|[[:human_genes:T:TBC1D3C|TBC1D3C]]|2.07|0.54|
|[[:human_genes:K:KRTAP9-7|KRTAP9-7]]|2.08|0.54|
|[[:human_genes:L:LMOD3|LMOD3]]|2.09|0.59|
|[[:human_genes:U:USP9X|USP9X]]|2.10|0.54|
|[[:human_genes:S:SEC23B|SEC23B]]|2.11|0.54|
|[[:human_genes:N:NUP43|NUP43]]|2.11|0.59|
|[[:human_genes:T:TARS|TARS]]|2.11|0.61|
|[[:human_genes:D:DUSP16|DUSP16]]|2.11|0.54|
|[[:human_genes:M:MMS22L|MMS22L]]|2.12|0.59|
|[[:human_genes:N:NUP98|NUP98]]|2.13|0.54|
|[[:human_genes:T:TUBA1C|TUBA1C]]|2.14|0.59|
|[[:human_genes:R:RRP7A|RRP7A]]|2.17|0.54|
|[[:human_genes:N:NOTCH2NL|NOTCH2NL]]|2.19|0.63|
|[[:human_genes:M:MDM2|MDM2]]|2.22|0.59|
|[[:human_genes:P:PSMD6|PSMD6]]|2.24|0.63|
|[[:human_genes:Y:YJEFN3|YJEFN3]]|2.28|0.29|
|[[:human_genes:N:NUP93|NUP93]]|2.32|0.59|
|[[:human_genes:S:SLC28A3|SLC28A3]]|2.32|0.29|
|[[:human_genes:S:SEC24C|SEC24C]]|2.35|0.29|
|[[:human_genes:N:NDC80|NDC80]]|2.38|0.61|
|[[:human_genes:B:BCL2L1|BCL2L1]]|2.48|0.21|
|[[:human_genes:G:GYPE|GYPE]]|2.49|0.54|
|[[:human_genes:S:SYVN1|SYVN1]]|3.07|0.21|
</modal>


<modal id="modal_screen_similarity" size="lg" title="Correlated Screens">
^Screen^Correlation^Plot^
|[[:results:exp68|Clomiphene 4.4μM R02 exp68]]|0.15|<button type="primary" size="small" modal="1">View</button>|
|[[:results:exp164|Q15 1 to 2μM on day4 R04 exp164]]|0.139|<button type="primary" size="small" modal="2">View</button>|
|[[:results:exp454|Bafilomycin-A1 0.009μM R08 exp454]]|0.121|<button type="primary" size="small" modal="3">View</button>|
|[[:results:exp89|Vemurafenib 6.6μM R02 exp89]]|0.102|<button type="primary" size="small" modal="4">View</button>|
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|0.098|<button type="primary" size="small" modal="5">View</button>|
|[[:results:exp90|WYE-354 6μM R02 exp90]]|0.098|<button type="primary" size="small" modal="6">View</button>|
|[[:results:exp469|CFI-400945 25μM R08 exp469]]|0.08|<button type="primary" size="small" modal="7">View</button>|
|[[:results:exp461|BS-181 20μM R08 exp461]]|0.078|<button type="primary" size="small" modal="8">View</button>|
|[[:results:exp131|L-74142 5μM R03 exp131]]|0.075|<button type="primary" size="small" modal="9">View</button>|
|[[:results:exp79|Q15 2.7μM R02 exp79]]|0.073|<button type="primary" size="small" modal="10">View</button>|
|[[:results:exp416|Tubacin 1.6μM R07 exp416]]|0.066|<button type="primary" size="small" modal="11">View</button>|
|[[:results:exp530|Thioridazine 5μM R08 exp530]]|0.065|<button type="primary" size="small" modal="12">View</button>|
|[[:results:exp227|Cryptotanshinone 12μM R05 exp227]]|0.064|<button type="primary" size="small" modal="13">View</button>|
|[[:results:exp182|IU1-47 25μM R04 exp182]]|0.061|<button type="primary" size="small" modal="14">View</button>|
|[[:results:exp442|Ibrutinib 10μM R08 exp442]]|0.059|<button type="primary" size="small" modal="15">View</button>|
|[[:results:exp538|ZLN024 50μM R08 exp538]]|0.059|<button type="primary" size="small" modal="16">View</button>|
|[[:results:exp326|CCT251545 20μM R07 exp326]]|0.058|<button type="primary" size="small" modal="17">View</button>|
|[[:results:exp77|Prochlorperazine 5.2μM R02 exp77]]|0.058|<button type="primary" size="small" modal="18">View</button>|
|[[:results:exp47|Lapatinib 5μM R01 exp47]]|0.057|<button type="primary" size="small" modal="19">View</button>|
|[[:results:exp226|Cerivastatin 0.15μM R05 exp226]]|0.057|<button type="primary" size="small" modal="20">View</button>|
|[[:results:exp507|Monensin 0.3μM R08 exp507]]|0.056|<button type="primary" size="small" modal="21">View</button>|
|[[:results:exp187|proTAME 5μM R04 exp187]]|0.056|<button type="primary" size="small" modal="22">View</button>|
|[[:results:exp233|EPZ-5676 30μM R05 exp233]]|0.055|<button type="primary" size="small" modal="23">View</button>|
|[[:results:exp149|SB203580 25μM R03 exp149]]|0.055|<button type="primary" size="small" modal="24">View</button>|
|[[:results:exp344|Chlorpromazine 10μM R07 exp344]]|0.053|<button type="primary" size="small" modal="25">View</button>|
|[[:results:exp463|Caffeine 2600μM R08 exp463]]|0.051|<button type="primary" size="small" modal="26">View</button>|
|[[:results:exp160|Ribavirin 10 to 15μM on day4 R04 exp160]]|0.051|<button type="primary" size="small" modal="27">View</button>|
</modal>


<modal id="1" size="lg" title="BH1 1μM R04 exp169  vs  Clomiphene 4.4μM R02 exp68">
{{:chemogenomics:comparison_plots:exp169_vs_exp68.png?nolink |}}
</modal>

<modal id="2" size="lg" title="BH1 1μM R04 exp169  vs  Q15 1 to 2μM on day4 R04 exp164">
{{:chemogenomics:comparison_plots:exp164_vs_exp169.png?nolink |}}
</modal>

<modal id="3" size="lg" title="BH1 1μM R04 exp169  vs  Bafilomycin-A1 0.009μM R08 exp454">
{{:chemogenomics:comparison_plots:exp169_vs_exp454.png?nolink |}}
</modal>

<modal id="4" size="lg" title="BH1 1μM R04 exp169  vs  Vemurafenib 6.6μM R02 exp89">
{{:chemogenomics:comparison_plots:exp169_vs_exp89.png?nolink |}}
</modal>

<modal id="5" size="lg" title="BH1 1μM R04 exp169  vs  Vemurafenib 6.6μM R08 exp434">
{{:chemogenomics:comparison_plots:exp169_vs_exp434.png?nolink |}}
</modal>

<modal id="6" size="lg" title="BH1 1μM R04 exp169  vs  WYE-354 6μM R02 exp90">
{{:chemogenomics:comparison_plots:exp169_vs_exp90.png?nolink |}}
</modal>

<modal id="7" size="lg" title="BH1 1μM R04 exp169  vs  CFI-400945 25μM R08 exp469">
{{:chemogenomics:comparison_plots:exp169_vs_exp469.png?nolink |}}
</modal>

<modal id="8" size="lg" title="BH1 1μM R04 exp169  vs  BS-181 20μM R08 exp461">
{{:chemogenomics:comparison_plots:exp169_vs_exp461.png?nolink |}}
</modal>

<modal id="9" size="lg" title="BH1 1μM R04 exp169  vs  L-74142 5μM R03 exp131">
{{:chemogenomics:comparison_plots:exp131_vs_exp169.png?nolink |}}
</modal>

<modal id="10" size="lg" title="BH1 1μM R04 exp169  vs  Q15 2.7μM R02 exp79">
{{:chemogenomics:comparison_plots:exp169_vs_exp79.png?nolink |}}
</modal>

<modal id="11" size="lg" title="BH1 1μM R04 exp169  vs  Tubacin 1.6μM R07 exp416">
{{:chemogenomics:comparison_plots:exp169_vs_exp416.png?nolink |}}
</modal>

<modal id="12" size="lg" title="BH1 1μM R04 exp169  vs  Thioridazine 5μM R08 exp530">
{{:chemogenomics:comparison_plots:exp169_vs_exp530.png?nolink |}}
</modal>

<modal id="13" size="lg" title="BH1 1μM R04 exp169  vs  Cryptotanshinone 12μM R05 exp227">
{{:chemogenomics:comparison_plots:exp169_vs_exp227.png?nolink |}}
</modal>

<modal id="14" size="lg" title="BH1 1μM R04 exp169  vs  IU1-47 25μM R04 exp182">
{{:chemogenomics:comparison_plots:exp169_vs_exp182.png?nolink |}}
</modal>

<modal id="15" size="lg" title="BH1 1μM R04 exp169  vs  Ibrutinib 10μM R08 exp442">
{{:chemogenomics:comparison_plots:exp169_vs_exp442.png?nolink |}}
</modal>

<modal id="16" size="lg" title="BH1 1μM R04 exp169  vs  ZLN024 50μM R08 exp538">
{{:chemogenomics:comparison_plots:exp169_vs_exp538.png?nolink |}}
</modal>

<modal id="17" size="lg" title="BH1 1μM R04 exp169  vs  CCT251545 20μM R07 exp326">
{{:chemogenomics:comparison_plots:exp169_vs_exp326.png?nolink |}}
</modal>

<modal id="18" size="lg" title="BH1 1μM R04 exp169  vs  Prochlorperazine 5.2μM R02 exp77">
{{:chemogenomics:comparison_plots:exp169_vs_exp77.png?nolink |}}
</modal>

<modal id="19" size="lg" title="BH1 1μM R04 exp169  vs  Lapatinib 5μM R01 exp47">
{{:chemogenomics:comparison_plots:exp169_vs_exp47.png?nolink |}}
</modal>

<modal id="20" size="lg" title="BH1 1μM R04 exp169  vs  Cerivastatin 0.15μM R05 exp226">
{{:chemogenomics:comparison_plots:exp169_vs_exp226.png?nolink |}}
</modal>

<modal id="21" size="lg" title="BH1 1μM R04 exp169  vs  Monensin 0.3μM R08 exp507">
{{:chemogenomics:comparison_plots:exp169_vs_exp507.png?nolink |}}
</modal>

<modal id="22" size="lg" title="BH1 1μM R04 exp169  vs  proTAME 5μM R04 exp187">
{{:chemogenomics:comparison_plots:exp169_vs_exp187.png?nolink |}}
</modal>

<modal id="23" size="lg" title="BH1 1μM R04 exp169  vs  EPZ-5676 30μM R05 exp233">
{{:chemogenomics:comparison_plots:exp169_vs_exp233.png?nolink |}}
</modal>

<modal id="24" size="lg" title="BH1 1μM R04 exp169  vs  SB203580 25μM R03 exp149">
{{:chemogenomics:comparison_plots:exp149_vs_exp169.png?nolink |}}
</modal>

<modal id="25" size="lg" title="BH1 1μM R04 exp169  vs  Chlorpromazine 10μM R07 exp344">
{{:chemogenomics:comparison_plots:exp169_vs_exp344.png?nolink |}}
</modal>

<modal id="26" size="lg" title="BH1 1μM R04 exp169  vs  Caffeine 2600μM R08 exp463">
{{:chemogenomics:comparison_plots:exp169_vs_exp463.png?nolink |}}
</modal>

<modal id="27" size="lg" title="BH1 1μM R04 exp169  vs  Ribavirin 10 to 15μM on day4 R04 exp160">
{{:chemogenomics:comparison_plots:exp160_vs_exp169.png?nolink |}}
</modal>



<modal id="modal_go_sensitive" size="lg" title="Top 30 sensitive GO terms">
^GO Term^Fold Change^Genes^
|sphinganine metabolic process|571.52|SPTLC1,SPTLC2|
|sphingomyelin biosynthetic process|228.61|SPTLC1,SGMS1,SPTLC2,OSBP|
|Golgi transport complex|214.32|COG5,COG7,COG6|
|retrograde transport, vesicle recycling within Golgi|214.32|COG5,COG7,COG6|
|sphingomyelin metabolic process|127.00|SPTLC1,SGMS1,SPTLC2,OSBP|
|sphingoid metabolic process|85.73|KDSR,SPTLC1,SPTLC2|
|intracellular cholesterol transport|71.44|LDLR,LDLRAP1,OSBP|
|regulation of cholesterol metabolic process|67.24|SCAP,LDLR,LDLRAP1,MBTPS1|
|intracellular sterol transport|61.23|LDLR,LDLRAP1,OSBP|
|intracellular lipid transport|54.43|CERT1,LDLR,LDLRAP1,OSBP|
|sphingolipid biosynthetic process|28.29|KDSR,SPTLC1,SGMS1,SPTLC2,OSBP|
|sphingolipid metabolic process|22.12|KDSR,SPTLC1,SGMS1,CERT1,SPTLC2,OSBP|
|Golgi organization|21.49|ARL1,COG5,DYM,COG7,COG6|
|membrane lipid biosynthetic process|20.41|KDSR,SPTLC1,SGMS1,SPTLC2,OSBP|
|membrane lipid metabolic process|16.98|KDSR,SPTLC1,SGMS1,CERT1,SPTLC2,OSBP|
|Golgi apparatus subcompartment|12.56|SGMS1,ARL1,COG5,COG7,TBC1D23,MBTPS1,OSBP,COG6|
|alcohol metabolic process|10.82|SCAP,SPTLC1,LDLR,LDLRAP1,MBTPS1,SPTLC2|
|Golgi membrane|8.71|SCAP,SGMS1,ARL1,COG5,ATP6V0A2,UNC50,COG7,MBTPS1,OSBP,COG6|
|organic hydroxy compound metabolic process|8.46|SCAP,SPTLC1,LDLR,LDLRAP1,MBTPS1,SPTLC2,OSBP|
</modal>
<modal id="modal_go_resistant" size="lg" title="Top 30 resistant GO terms">
^GO Term^Fold Change^Genes^
|nuclear pore outer ring|207.18|NUP98,NUP43,SEC13|
|COPII-coated vesicle cargo loading|118.39|SEC24C,SEC23B,SEC31A|
|COPII vesicle coat|110.49|SEC24C,SEC23B,SEC13|
|structural constituent of nuclear pore|72.06|NUP93,NUP98,NUP188|
|vesicle cargo loading|71.29|SEC24C,SEC23B,SEC13,SEC31A|
|COPII-coated vesicle budding|58.15|SEC24C,SEC23B,SEC13,SEC31A|
|ER to Golgi transport vesicle membrane|37.46|SEC24C,SEC23B,SEC13,SEC31A|
|nuclear pore|30.03|NUP93,NUP98,NUP43,SEC13,NUP188|
|vesicle budding from membrane|29.86|SEC24C,SEC23B,SEC13,SEC31A|
|mRNA transport|24.23|NUP93,NUP98,NUP43,SEC13,NUP188|
|RNA transport|19.59|NUP93,NUP98,NUP43,SEC13,NUP188|
|nucleic acid transport|19.59|NUP93,NUP98,NUP43,SEC13,NUP188|
|establishment of RNA localization|19.32|NUP93,NUP98,NUP43,SEC13,NUP188|
|protein localization to nucleus|18.11|NUP93,MDM2,RRP7A,NUP98,SEC13,NUP188|
|nucleobase-containing compound transport|16.09|SLC28A3,NUP93,NUP98,NUP43,SEC13,NUP188|
|transport vesicle membrane|14.67|BCL2L1,SEC24C,SEC23B,SEC13,ATP6AP1,SEC31A|
|nucleocytoplasmic transport|14.17|NUP93,NUP98,DUSP16,NUP43,SEC13,NUP188|
|nuclear transport|14.17|NUP93,NUP98,DUSP16,NUP43,SEC13,NUP188|
|intracellular protein transport|8.16|SYVN1,SEC24C,NUP93,DUSP16,SEC23B,USP9X,SEC13,NUP188,ATP6AP1,SEC31A|
</modal>