Nicotinamide Riboside 100μM R03 exp139 [The Human Chemical-Genetic Interaction Map Project]

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====== Nicotinamide Riboside 100μM R03 exp139 ======
==== Mechanism of Action ====
NAD precursor, activates SIRT1
  * **<color #00a2e8>Class / Subclass 1:</color>** Metabolism / Metabolite




==== Technical Notes ====
<accordion collapsed='true'>
<panel title='Compound References' collapsed='true'>
    * **<color #00a2e8>PubChem Name:</color>** %%Nicotinamide riboside chloride%%
    * **<color #00a2e8>Synonyms:</color>** N/A
    * **<color #00a2e8>CAS #:</color>** 23111-00-4
    * **<color #00a2e8>PubChem CID:</color>** [[https://pubchem.ncbi.nlm.nih.gov/compound/90480033|90480033]]
    * **<color #00a2e8>IUPAC:</color>** %%1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]pyridin-1-ium-3-carboxamide;chloride%%
    * **<color #00a2e8>INCHI Name:</color>** InChI=1S/C11H14N2O5.ClH/c12-10(17)6-2-1-3-13(4-6)11-9(16)8(15)7(5-14)18-11;/h1-4,7-9,11,14-16H,5H2,(H-,12,17);1H/t7-,8-,9-,11-;/m1./s1
    * **<color #00a2e8>INCHI Key:</color>** YABIFCKURFRPPO-IVOJBTPCSA-N
    * **<color #00a2e8>Molecular Weight:</color>** 290.7
    * **<color #00a2e8>Canonical SMILES:</color>** C1=CC(=C[N+](=C1)C2C(C(C(O2)CO)O)O)C(=O)N.[Cl-]
    * **<color #00a2e8>Isomeric SMILES:</color>** C1=CC(=C[N+](=C1)[C@H]2[C@@H]([C@@H]([C@H](O2)CO)O)O)C(=O)N.[Cl-]
    * **<color #00a2e8>Molecular Formula:</color>** C11H15ClN2O5
{{:chemogenomics:structures:chem-0090.svg?nolink}}
</panel>


<panel title='Compound Supplier' collapsed='true'>
    * **<color #00a2e8>Supplier Name:</color>** BioSynth (Charles Brenner)
    * **<color #00a2e8>Catalog #:</color>** N/A
    * **<color #00a2e8>Lot #:</color>** N/A
</panel>


<panel title='Compound Characterization' collapsed='true'>
    * **<color #00a2e8>HRMS (ESI-TOF) m/z:</color>** [M]+ Calcd for C11H15N2O5 255.0975; found 255.0959
    * **<color #00a2e8>HRMS (ESI-TOF) m/z:</color>** [M+H-C5H9O4+]+ Calcd for C6H7N2O 123.0553; found 123.0536
</panel>


<panel title='Dose Response Curve' collapsed='true'>
    * **<color #00a2e8>Platform ID:</color>** NICOTINAMIDE-RIBOSE
    * **<color #00a2e8>Min:</color>** -3.4168; **<color #00a2e8>Max:</color>** 11.4802
{{:chemogenomics:dose_response:dr_103.png?nolink&500 |}}
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|< 300px 100px 200px >|
^ IC   ^ Concentration (µM) ^
| IC10  |N/A    |
| IC20  |N/A    |
| IC30  |N/A    |
| IC40  |N/A    |
| IC50  |N/A    |
| IC60  |N/A    |
| IC70  |N/A    |
| IC80  |N/A    |
| IC90  |N/A    |
\\ 
</panel>
</accordion>
==== Screen Summary ====
    * **<color #00a2e8>Round</color>**: 03
    * **<color #00a2e8>Dose</color>**: 100µM
    * **<color #00a2e8>Days of incubation</color>**: 8
    * **<color #00a2e8>Doublings</color>**: 7.9
    * **<color #00a2e8>Numbers of reads</color>**: 11225449


==== Screen Results ====


^Sensitive/Resistant hits (FDR<0.05)^CRANKS^Score Plot^Top 30 Genes^Screen Similarity^Top 30 Sensitive GO terms^Top 30 Resistant GO terms^
|0/0|<color #e85500>[[https://files.tyerslab.com/files/public/chemogenomics/cranks/Nicotinamide_Riboside_100uM_Round-3_exp139.txt|Scores]]</color>|<button type="primary" size="sm" modal="ScorePlot">View</button>|<button type="primary" size="sm" modal="modal_hits">View</button>|<button type="primary" size="sm" modal="modal_screen_similarity">View</button>|<button type="default" size="sm" modal="modal_go_sensitive">View</button>|<button type="primary" size="sm" modal="modal_go_resistant">View</button>|
<modal id='ScorePlot' size='lg' title='Nicotinamide Riboside 100μM R03 exp139'>
{{:chemogenomics:cranks_plots:exp139.png?nolink}}
</modal>


<modal id="modal_hits" size="sm" title="Top 30 S/R Genes">
^Gene^CRANKS Score^FDR^
|[[:human_genes:U:UHRF1|UHRF1]]|-2.57|0.48|
|[[:human_genes:C:C8orf82|C8orf82]]|-2.36|0.48|
|[[:human_genes:C:CCDC101|CCDC101]]|-2.34|0.48|
|[[:human_genes:P:PGGT1B|PGGT1B]]|-2.24|0.48|
|[[:human_genes:T:TEN1|TEN1]]|-2.18|0.49|
|[[:human_genes:S:SETX|SETX]]|-2.17|0.60|
|[[:human_genes:D:DNAJC5|DNAJC5]]|-2.16|0.60|
|[[:human_genes:F:FH|FH]]|-2.15|0.60|
|[[:human_genes:C:C12orf61|C12orf61]]|-2.07|0.60|
|[[:human_genes:S:SEPSECS|SEPSECS]]|-2.05|0.60|
|[[:human_genes:P:PNKP|PNKP]]|-2.03|0.68|
|[[:human_genes:T:TMX1|TMX1]]|-2.02|0.60|
|[[:human_genes:F:FOXB1|FOXB1]]|-1.98|0.60|
|[[:human_genes:M:MT3|MT3]]|-1.98|0.60|
|[[:human_genes:L:LOC100129697|LOC100129697]]|-1.97|0.60|
|[[:human_genes:T:TNS3|TNS3]]|-1.96|0.60|
|[[:human_genes:C:COQ6|COQ6]]|-1.96|0.60|
|[[:human_genes:Z:ZMYM1|ZMYM1]]|-1.94|0.60|
|[[:human_genes:Z:ZNF605|ZNF605]]|-1.93|0.60|
|[[:human_genes:P:PROK2|PROK2]]|-1.93|0.62|
|[[:human_genes:T:TGIF2LX|TGIF2LX]]|-1.92|0.60|
|[[:human_genes:C:CAPN13|CAPN13]]|-1.91|0.60|
|[[:human_genes:R:RNMT|RNMT]]|-1.90|0.60|
|[[:human_genes:S:SPIRE2|SPIRE2]]|-1.88|0.60|
|[[:human_genes:C:CEP76|CEP76]]|-1.86|0.60|
|[[:human_genes:P:PHF6|PHF6]]|-1.85|0.60|
|[[:human_genes:H:HOXD13|HOXD13]]|-1.85|0.60|
|[[:human_genes:O:OR2T10|OR2T10]]|-1.85|0.60|
|[[:human_genes:C:CLMP|CLMP]]|-1.85|0.60|
|[[:human_genes:P:PDK3|PDK3]]|-1.84|0.60|
|[[:human_genes:T:TONSL|TONSL]]|1.90|0.73|
|[[:human_genes:S:SLC14A2|SLC14A2]]|1.90|0.73|
|[[:human_genes:O:OPTN|OPTN]]|1.90|0.76|
|[[:human_genes:P:PI4KB|PI4KB]]|1.90|0.73|
|[[:human_genes:C:CRYL1|CRYL1]]|1.90|0.73|
|[[:human_genes:O:OR1K1|OR1K1]]|1.90|0.76|
|[[:human_genes:P:PSMB3|PSMB3]]|1.90|0.76|
|[[:human_genes:F:FAM50A|FAM50A]]|1.91|0.76|
|[[:human_genes:M:MGAT4D|MGAT4D]]|1.92|0.77|
|[[:human_genes:M:MS4A13|MS4A13]]|1.93|0.77|
|[[:human_genes:R:RFC4|RFC4]]|1.93|0.76|
|[[:human_genes:O:OR2T27|OR2T27]]|1.93|0.76|
|[[:human_genes:C:C8B|C8B]]|1.98|0.73|
|[[:human_genes:S:SEPT10|SEPT10]]|2.01|0.73|
|[[:human_genes:B:BRIX1|BRIX1]]|2.03|0.73|
|[[:human_genes:O:OR51G2|OR51G2]]|2.03|0.73|
|[[:human_genes:T:TXNL1|TXNL1]]|2.04|0.73|
|[[:human_genes:C:CSF1|CSF1]]|2.05|0.73|
|[[:human_genes:R:RPA1|RPA1]]|2.08|0.76|
|[[:human_genes:S:SMG5|SMG5]]|2.10|0.76|
|[[:human_genes:A:ATXN2L|ATXN2L]]|2.11|0.73|
|[[:human_genes:P:POLR2J|POLR2J]]|2.12|0.76|
|[[:human_genes:K:KIAA1257|KIAA1257]]|2.22|0.73|
|[[:human_genes:N:NEUROD1|NEUROD1]]|2.24|0.73|
|[[:human_genes:R:RARS|RARS]]|2.25|0.76|
|[[:human_genes:K:KIR3DL3|KIR3DL3]]|2.28|0.73|
|[[:human_genes:E:EIF5|EIF5]]|2.30|0.73|
|[[:human_genes:R:RFC1|RFC1]]|2.39|0.76|
|[[:human_genes:N:NUP88|NUP88]]|2.39|0.73|
|[[:human_genes:R:RRM1|RRM1]]|2.65|0.73|
</modal>


<modal id="modal_screen_similarity" size="lg" title="Correlated Screens">
^Screen^Correlation^Plot^
|[[:results:exp476|Dihydrosphingosine 8μM R08 exp476]]|0.057|<button type="primary" size="small" modal="1">View</button>|
</modal>


<modal id="1" size="lg" title="Dihydrosphingosine 8μM R08 exp476  vs  Nicotinamide Riboside 100μM R03 exp139">
{{:chemogenomics:comparison_plots:exp139_vs_exp476.png?nolink |}}
</modal>



<modal id="modal_go_sensitive" size="lg" title="Top 30 sensitive GO terms">No GO term hits below threshold. (FDR <0.05)</modal>
<modal id="modal_go_resistant" size="lg" title="Top 30 resistant GO terms">
^GO Term^Fold Change^Genes^
|replication fork|34.54|RFC1,RPA1,RFC4,TONSL|
|DNA-templated DNA replication|20.93|RRM1,RFC1,RPA1,RFC4,TONSL|
</modal>