MGAT4D

Entrez Summary: N/A
UniProt Summary: May play a role in male spermatogenesis. In vitro acts as inhibitor of MGAT1 activity causing cell surface proteins to carry mainly high mannose N-glycans. The function is mediated by its lumenal domain and occurs specifically in the Golgi. A catalytic glucosyltransferase activity is not detected. May be involved in regulation of Sertoli-germ cell interactions during specific stages of spermatogenesis. {ECO:0000250|UniProtKB:Q9D4R2}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Rapamycin 0.001μM R08 exp429	-1.96
Quercetin 20μM R08 exp517	-1.9
Hypoxia 5%O2 R04 exp191	-1.86
UM0130462 0.025 to 0.035μM day4 R05 exp247	-1.86
Nutlin-3A 1.6μM R06 exp294	-1.74
Clomiphene 4.4μM R02 exp68	-1.7
Nicotinamide Riboside 100μM R03 exp139	1.92
UMK57 1μM R01 exp59	1.94
Bisphenol F 50μM R08 exp457	1.95
SGC0946 7μM R03 exp151	2.04
Golgicide-A 4μM R03 exp122	2.07
CAY10603 0.55μM R08 exp467	2.12
Hydroxyurea 100μM R07 exp329	2.13
Chloramphenicol 2μM R00 exp12	2.45
Beta-Estradiol 0.55μM R07 exp425	2.6
Pifithrin-alpha 20μM R07 exp390	2.8

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Gene	Correlation
RUVBL2	0.448
HGC6.3	0.417

negative regulation of protein glycosylation
negative regulation of glycoprotein biosynthetic process
regulation of protein glycosylation
negative regulation of glycoprotein metabolic process
acetylglucosaminyltransferase activity
Golgi stack
regulation of glycoprotein biosynthetic process
regulation of glycoprotein metabolic process
endoplasmic reticulum-Golgi intermediate compartment
protein N-linked glycosylation
macromolecule glycosylation
protein glycosylation
glycosylation
glycoprotein biosynthetic process
glycoprotein metabolic process
spermatogenesis
male gamete generation
negative regulation of protein modification process
carbohydrate derivative biosynthetic process
Golgi membrane
gamete generation
multicellular organismal reproductive process
sexual reproduction
multicellular organism reproduction
endoplasmic reticulum membrane
multi-organism reproductive process
endoplasmic reticulum
carbohydrate derivative metabolic process
negative regulation of cellular protein metabolic process
negative regulation of protein metabolic process
negative regulation of cellular macromolecule biosynthetic process
organonitrogen compound biosynthetic process
reproductive process
reproduction
negative regulation of macromolecule biosynthetic process
negative regulation of cellular biosynthetic process
negative regulation of biosynthetic process
cellular macromolecule biosynthetic process
macromolecule biosynthetic process
regulation of protein modification process