MGAT4D [The Human Chemical-Genetic Interaction Map Project]

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======= MGAT4D =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MGAT4D
  * **<color #00a2e8>Official Name</color>**: MGAT4 family member D
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=152586|152586]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/A6NG13|A6NG13]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MGAT4D&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MGAT4D|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/610310|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  May play a role in male spermatogenesis. In vitro acts as inhibitor of MGAT1 activity causing cell surface proteins to carry mainly high mannose N-glycans. The function is mediated by its lumenal domain and occurs specifically in the Golgi. A catalytic glucosyltransferase activity is not detected. May be involved in regulation of Sertoli-germ cell interactions during specific stages of spermatogenesis. {ECO:0000250|UniProtKB:Q9D4R2}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Glyco transf 54|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of protein glycosylation|
|negative regulation of glycoprotein biosynthetic process|
|regulation of protein glycosylation|
|negative regulation of glycoprotein metabolic process|
|acetylglucosaminyltransferase activity|
|Golgi stack|
|regulation of glycoprotein biosynthetic process|
|regulation of glycoprotein metabolic process|
|endoplasmic reticulum-Golgi intermediate compartment|
|protein N-linked glycosylation|
|macromolecule glycosylation|
|protein glycosylation|
|glycosylation|
|glycoprotein biosynthetic process|
|glycoprotein metabolic process|
|spermatogenesis|
|male gamete generation|
|negative regulation of protein modification process|
|carbohydrate derivative biosynthetic process|
|Golgi membrane|
|gamete generation|
|multicellular organismal reproductive process|
|sexual reproduction|
|multicellular organism reproduction|
|endoplasmic reticulum membrane|
|multi-organism reproductive process|
|endoplasmic reticulum|
|carbohydrate derivative metabolic process|
|negative regulation of cellular protein metabolic process|
|negative regulation of protein metabolic process|
|negative regulation of cellular macromolecule biosynthetic process|
|organonitrogen compound biosynthetic process|
|reproductive process|
|reproduction|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|negative regulation of biosynthetic process|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|regulation of protein modification process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp429|Rapamycin 0.001μM R08 exp429]]|-1.96|
|[[:results:exp517|Quercetin 20μM R08 exp517]]|-1.9|
|[[:results:exp191|Hypoxia 5%O2 R04 exp191]]|-1.86|
|[[:results:exp247|UM0130462 0.025 to 0.035μM day4 R05 exp247]]|-1.86|
|[[:results:exp294|Nutlin-3A 1.6μM R06 exp294]]|-1.74|
|[[:results:exp68|Clomiphene 4.4μM R02 exp68]]|-1.7|
|[[:results:exp139|Nicotinamide Riboside 100μM R03 exp139]]|1.92|
|[[:results:exp59|UMK57 1μM R01 exp59]]|1.94|
|[[:results:exp457|Bisphenol F 50μM R08 exp457]]|1.95|
|[[:results:exp151|SGC0946 7μM R03 exp151]]|2.04|
|[[:results:exp122|Golgicide-A 4μM R03 exp122]]|2.07|
|[[:results:exp467|CAY10603 0.55μM R08 exp467]]|2.12|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|2.13|
|[[:results:exp12|Chloramphenicol 2μM R00 exp12]]|2.45|
|[[:results:exp425|Beta-Estradiol 0.55μM R07 exp425]]|2.6|
|[[:results:exp390|Pifithrin-alpha 20μM R07 exp390]]|2.8|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:ruvbl2|RUVBL2]]|0.448|
|[[:human genes:h:hgc6.3|HGC6.3]]|0.417|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 16820
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -5.01 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MGAT4D Expression in NALM6 Cells: -5.01'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>