CEP76

Entrez Summary: N/A
UniProt Summary: Centrosomal protein involved in regulation of centriole duplication. Required to limit centriole duplication to once per cell cycle by preventing centriole reduplication. {ECO:0000269|PubMed:19460342}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
A-769662 20μM R07 exp331	-2.21
LY2090314 0.003μM R08 exp499	-2.2
Amiloride 100μM R08 exp447	-1.91
Nicotinamide Riboside 100μM R03 exp139	-1.86
GSK-J4 1μM R07 exp362	-1.82
NFN1 1μM R03 exp100	-1.73
Genistein 15μM R07 exp360	2.11
DABN 2μM R00 exp16	2.63
RO-3307 4.7μM R02 exp80	2.8
Cytochalasin-B 5μM R07 exp349	4.65
Latrunculin-B 10μM R07 exp374	5.7
Tozasertib 0.1μM R07 exp414	5.94

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

regulation of centriole replication
regulation of centrosome duplication
regulation of centrosome cycle
ciliary basal body-plasma membrane docking
G2/M transition of mitotic cell cycle
cell cycle G2/M phase transition
centriole
organelle localization by membrane tethering
membrane docking
regulation of microtubule cytoskeleton organization
regulation of G2/M transition of mitotic cell cycle
regulation of cell cycle G2/M phase transition
regulation of organelle assembly
regulation of microtubule-based process
mitotic cell cycle phase transition
cell cycle phase transition
cilium assembly
cilium organization
regulation of mitotic cell cycle phase transition
plasma membrane bounded cell projection assembly
regulation of cell cycle phase transition
cell projection assembly
centrosome
regulation of cytoskeleton organization
organelle localization
protein-containing complex
mitotic cell cycle process
regulation of mitotic cell cycle
mitotic cell cycle
regulation of cell cycle process
organelle assembly
regulation of cellular component biogenesis
cell cycle process
plasma membrane bounded cell projection organization
cell projection organization
regulation of cell cycle
regulation of organelle organization
cell cycle