CEP76 [The Human Chemical-Genetic Interaction Map Project]

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======= CEP76 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CEP76
  * **<color #00a2e8>Official Name</color>**: centrosomal protein 76
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=79959|79959]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8TAP6|Q8TAP6]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CEP76&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CEP76|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/620791|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Centrosomal protein involved in regulation of centriole duplication. Required to limit centriole duplication to once per cell cycle by preventing centriole reduplication. {ECO:0000269|PubMed:19460342}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of centriole replication|
|regulation of centrosome duplication|
|regulation of centrosome cycle|
|ciliary basal body-plasma membrane docking|
|G2/M transition of mitotic cell cycle|
|cell cycle G2/M phase transition|
|centriole|
|organelle localization by membrane tethering|
|membrane docking|
|regulation of microtubule cytoskeleton organization|
|regulation of G2/M transition of mitotic cell cycle|
|regulation of cell cycle G2/M phase transition|
|regulation of organelle assembly|
|regulation of microtubule-based process|
|mitotic cell cycle phase transition|
|cell cycle phase transition|
|cilium assembly|
|cilium organization|
|regulation of mitotic cell cycle phase transition|
|plasma membrane bounded cell projection assembly|
|regulation of cell cycle phase transition|
|cell projection assembly|
|centrosome|
|regulation of cytoskeleton organization|
|organelle localization|
|protein-containing complex|
|mitotic cell cycle process|
|regulation of mitotic cell cycle|
|mitotic cell cycle|
|regulation of cell cycle process|
|organelle assembly|
|regulation of cellular component biogenesis|
|cell cycle process|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|regulation of cell cycle|
|regulation of organelle organization|
|cell cycle|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp331|A-769662 20μM R07 exp331]]|-2.21|
|[[:results:exp499|LY2090314 0.003μM R08 exp499]]|-2.2|
|[[:results:exp447|Amiloride 100μM R08 exp447]]|-1.91|
|[[:results:exp139|Nicotinamide Riboside 100μM R03 exp139]]|-1.86|
|[[:results:exp362|GSK-J4 1μM R07 exp362]]|-1.82|
|[[:results:exp100|NFN1 1μM R03 exp100]]|-1.73|
|[[:results:exp360|Genistein 15μM R07 exp360]]|2.11|
|[[:results:exp16|DABN 2μM R00 exp16]]|2.63|
|[[:results:exp80|RO-3307 4.7μM R02 exp80]]|2.8|
|[[:results:exp349|Cytochalasin-B 5μM R07 exp349]]|4.65|
|[[:results:exp374|Latrunculin-B 10μM R07 exp374]]|5.7|
|[[:results:exp414|Tozasertib 0.1μM R07 exp414]]|5.94|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:o:odf2|ODF2]]|0.639|
|[[:human genes:c:cradd|CRADD]]|0.636|
|[[:human genes:c:ccdc41|CCDC41]]|0.627|
|[[:human genes:c:cep128|CEP128]]|0.624|
|[[:human genes:p:pibf1|PIBF1]]|0.622|
|[[:human genes:c:casp2|CASP2]]|0.618|
|[[:human genes:c:c2cd3|C2CD3]]|0.615|
|[[:human genes:s:sclt1|SCLT1]]|0.596|
|[[:human genes:p:pidd|PIDD]]|0.588|
|[[:human genes:k:kiaa0753|KIAA0753]]|0.586|
|[[:human genes:o:ofd1|OFD1]]|0.576|
|[[:human genes:a:ankrd26|ANKRD26]]|0.563|
|[[:human genes:n:nin|NIN]]|0.521|
|[[:human genes:c:cep120|CEP120]]|0.52|
|[[:human genes:c:c16orf59|C16orf59]]|0.499|
|[[:human genes:f:fopnl|FOPNL]]|0.487|
|[[:human genes:c:c14orf80|C14orf80]]|0.474|
|[[:human genes:h:hyls1|HYLS1]]|0.441|
|[[:human genes:c:cep44|CEP44]]|0.435|
|[[:human genes:c:cep78|CEP78]]|0.412|
|[[:human genes:t:tubd1|TUBD1]]|0.402|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 12555
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.68 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CEP76 Expression in NALM6 Cells: 4.68'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>