PIBF1

Gene Information

Official Symbol: PIBF1
Official Name: progesterone immunomodulatory binding factor 1
Aliases and Previous Symbols: N/A
Entrez ID: 10464
UniProt: Q8WXW3
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes a protein that is induced by the steroid hormone progesterone and plays a role in the maintenance of pregnancy. The encoded protein regulates multiple facets of the immune system to promote normal pregnancy including cytokine synthesis, natural killer (NK) cell activity, and arachidonic acid metabolism. Low serum levels of this protein have been associated with spontaneous pre-term labor in humans. This protein may promote the proliferation, migration and invasion of glioma. [provided by RefSeq, Mar 2017].
UniProt Summary: Isoform 1: Pericentriolar protein required to maintain mitotic spindle pole integrity (PubMed:21224392). Required for the centrosomal accumulation of PCM1 and the recruitment of centriolar satellite proteins such as BBS4. Via association with PCM1 may be involved in primary cilia formation (PubMed:23110211). Required for CEP63 centrosomal localization and its interaction with WDR62. Together with CEP63 promotes centriole duplication. Promotes the centrosomal localization of CDK2 (PubMed:26297806). {ECO:0000269|PubMed:21224392, ECO:0000269|PubMed:23110211, ECO:0000269|PubMed:26297806}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
BI-6727 0.0125μM R03 exp97	-1.72
LLY-283 2.6μM R06 exp290	1.7
Cycloheximide 0.02μM R00 exp14	1.71
ML-792 0.2μM R08 exp505	1.8
UM131593 0.1μM R01 exp58	1.8
Suberoylanilide-Hydroxamic-Acid 0.02μM R01 exp53	1.86
Dorsomorphin 5μM R07 exp357	1.99
RO-3307 4.7μM R02 exp80	2.84
Latrunculin-B 10μM R07 exp374	6.43
Cytochalasin-B 5μM R07 exp349	6.48
Tozasertib 0.1μM R07 exp414	7.55

Gene	Correlation
CASP2	0.71
C2CD3	0.689
ODF2	0.672
CRADD	0.668
CCDC41	0.661
PIDD	0.653
KIAA0753	0.646
CEP76	0.622
OFD1	0.621
C14orf80	0.599
SCLT1	0.598
NIN	0.576
C16orf59	0.572
ANKRD26	0.572
CEP120	0.57
TUBD1	0.568
FOPNL	0.561
CEP128	0.53
CEP78	0.503
TUBE1	0.487
HYLS1	0.45
CEP44	0.434
RTTN	0.434
KIAA0586	0.422

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 17975
Expression level (log2 read counts): 4.0

Expression Distribution

negative regulation of prostaglandin biosynthetic process
interleukin-4 receptor binding
activation of Janus kinase activity
negative regulation of natural killer cell activation
regulation of prostaglandin biosynthetic process
regulation of unsaturated fatty acid biosynthetic process
negative regulation of tyrosine phosphorylation of STAT protein
negative regulation of fatty acid biosynthetic process
negative regulation of interleukin-12 production
negative regulation of receptor signaling pathway via JAK-STAT
negative regulation of receptor signaling pathway via STAT
protein localization to centrosome
protein localization to microtubule organizing center
negative regulation of fatty acid metabolic process
centriolar satellite
regulation of natural killer cell activation
protein localization to microtubule cytoskeleton
positive regulation of interleukin-10 production
mitotic spindle assembly
protein localization to cytoskeleton
non-motile cilium assembly
regulation of fatty acid biosynthetic process
mitotic metaphase plate congression
negative regulation of lipid biosynthetic process
negative regulation of peptidyl-tyrosine phosphorylation
regulation of interleukin-10 production
regulation of interleukin-12 production
metaphase plate congression
positive regulation of tyrosine phosphorylation of STAT protein
establishment of chromosome localization
chromosome localization
mitotic spindle organization
regulation of tyrosine phosphorylation of STAT protein
negative regulation of lipid metabolic process
positive regulation of receptor signaling pathway via JAK-STAT
regulation of fatty acid metabolic process
positive regulation of receptor signaling pathway via STAT
negative regulation of small molecule metabolic process
spindle assembly
microtubule cytoskeleton organization involved in mitosis