TTL

Entrez Summary: N/A
UniProt Summary: Catalyzes the post-translational addition of a tyrosine to the C-terminal end of detyrosinated alpha-tubulin. {ECO:0000269|PubMed:25908662}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Gene	Correlation
KATNA1	0.437
KIF18B	0.415

tubulin-tyrosine ligase activity
C-terminal protein-tyrosinylation
protein tyrosinylation
regulation of metaphase plate congression
C-terminal protein amino acid modification
cell
regulation of axon extension
regulation of chromosome segregation
regulation of extent of cell growth
peptidyl-tyrosine modification
positive regulation of mitotic cell cycle
regulation of cell size
regulation of axonogenesis
regulation of cell morphogenesis involved in differentiation
regulation of developmental growth
post-translational protein modification
regulation of cellular component size
positive regulation of cell cycle
regulation of cell growth
microtubule cytoskeleton organization
regulation of cell morphogenesis
regulation of neuron projection development
regulation of anatomical structure size
regulation of mitotic cell cycle
regulation of neuron differentiation
regulation of growth
microtubule-based process
regulation of plasma membrane bounded cell projection organization
regulation of cell projection organization
regulation of cell cycle process
regulation of neurogenesis
peptidyl-amino acid modification
regulation of cellular localization
regulation of nervous system development
regulation of cell development
regulation of anatomical structure morphogenesis
cytoskeleton organization
regulation of cell cycle
ATP binding
generation of neurons