GRPEL1

Entrez Summary: N/A
UniProt Summary: Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner (By similarity). Seems to control the nucleotide-dependent binding of mitochondrial HSP70 to substrate proteins (PubMed:11311562). {ECO:0000250|UniProtKB:P38523, ECO:0000269|PubMed:11311562}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Rotenone 0.07μM R08 exp431	-2.32
GSK-J4 1μM R07 exp362	-1.94
GSK-J4 1-1.25μM to day4 R07 exp363	-1.81
Adefovir 20μM R07 exp332	-1.8
CCCP 1μM R00 exp11	-1.71
Salinomycin 3.5μM R08 exp521	1.7
Torin1 0.08μM R02 exp82	1.72
BI-6727 0.04μM R03 exp98	1.76
Trientine 500μM R08 exp534	1.81
Bafilomycin-A1 0.009μM R08 exp454	1.85
Caffeine 2600μM R08 exp463	1.88
Actinomycin-D 0.001μM R00 exp3	1.91
Quercetin 20μM R08 exp517	1.91
Cryptotanshinone 12μM R05 exp227	1.92
Rotenone 20μM R00 exp34	1.95
Combretastatin A4 0.002 to 0.003μM day4 R04 exp179	2.09
CR131-b 0.005μM R08 exp474	2.09
Etoposide 0.3μM R05 exp199	2.2
Etoposide 1μM R00 exp19	2.27
HMS-I1 1μM R01 exp46	2.28
WYE-354 6μM R02 exp90	2.35
5-Fluorouracil 20μM R00 exp2	2.79

Global Fraction of Cell Lines Where Essential: 641/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	1/1
bile duct	22/28
blood	23/28
bone	24/26
breast	28/33
central nervous system	47/56
cervix	4/4
colorectal	16/17
esophagus	10/13
fibroblast	1/1
gastric	14/16
kidney	15/21
liver	14/20
lung	68/75
lymphocyte	15/16
ovary	26/26
pancreas	20/24
peripheral nervous system	16/16
plasma cell	14/15
prostate	1/1
skin	24/24
soft tissue	6/9
thyroid	2/2
upper aerodigestive	16/22
urinary tract	23/29
uterus	5/5

Expression Distribution

PAM complex, Tim23 associated import motor
adenyl-nucleotide exchange factor activity
protein import into mitochondrial matrix
protein transmembrane import into intracellular organelle
intracellular protein transmembrane transport
protein targeting to mitochondrion
protein transmembrane transport
establishment of protein localization to mitochondrion
protein localization to mitochondrion
mitochondrial transmembrane transport
chaperone binding
unfolded protein binding
protein import
mitochondrial transport
protein folding
protein targeting
mitochondrial matrix
establishment of protein localization to organelle
mitochondrion organization
protein localization to organelle
protein homodimerization activity
intracellular protein transport
mitochondrion
transmembrane transport
protein transport
intracellular transport
peptide transport
amide transport
cellular protein localization
cellular macromolecule localization
establishment of protein localization
establishment of localization in cell
nitrogen compound transport