LCMT1

Gene Information

Official Symbol: LCMT1
Official Name: leucine carboxyl methyltransferase 1
Aliases and Previous Symbols: N/A
Entrez ID: 51451
UniProt: Q9UIC8
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Methylates the carboxyl group of the C-terminal leucine residue of protein phosphatase 2A catalytic subunits to form alpha-leucine ester residues. {ECO:0000269|PubMed:10600115}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
ETC-159 50μM R08 exp480	-3.93
GSK461364A 0.005μM R03 exp125	-3.19
39°C R06 exp303	-3.18
MK-1775 0.32μM R02 exp75	-2.71
Arsenate 40μM R06 exp264	-2.68
YM155 0.001μM R08 exp432	-2.65
BI-6727 0.0125μM R03 exp97	-2.58
BI-2536 0.0042μM R03 exp95	-2.5
Vincristine 0.0005μM R04 exp190	-2.35
Cryptotanshinone 12μM R05 exp227	-2.34
Menadione 5μM R06 exp292	-2.22
B02 10μM R08 exp453	-2.19
Pterostilbene 16μM R02 exp78	-2.11
AICAR 240μM R05 exp211	-1.86
LB-100 2μM R05 exp210	-1.83
AICAR 240μM R03 exp116	-1.82
Rotenone 20μM R00 exp34	1.84
Vemurafenib 6.6μM R08 exp434	2
Wortmannin 5μM R00 exp38	2.34
HMS-I1 1μM R01 exp46	2.87
RO-3307 4.7μM R02 exp80	3
2-Methoxyestradiol 0.55 to 0.75μM on day4 R07 exp311	3.1
BML-284 0.09μM R08 exp460	3.12
Dorsomorphin 5μM R07 exp357	3.32
2-Methoxyestradiol 0.55 to 1μM on day4 R07 exp312	5.04
BVD-523 15μM R02 exp67	5.45
UMK57 1μM R01 exp59	5.73
Milciclib 2μM R08 exp502	5.75
Mdivi-1 15μM R05 exp217	6.45

Global Fraction of Cell Lines Where Essential: 41/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	1/28
blood	1/28
bone	0/26
breast	1/33
central nervous system	2/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	1/16
kidney	2/21
liver	0/20
lung	2/75
lymphocyte	1/16
ovary	4/26
pancreas	2/24
peripheral nervous system	0/16
plasma cell	2/15
prostate	0/1
skin	7/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 2646
Expression level (log2 read counts): 3.61

Expression Distribution

Gene	Correlation
PPP2R1A	0.721
PPME1	0.656
TIPRL	0.604
PPP2R4	0.595
PPP2R5C	0.49
PPP2R2A	0.47
PPP6C	0.459
CBX3	0.446
CYB5R4	0.433

protein C-terminal leucine carboxyl O-methyltransferase activity
C-terminal protein methylation
protein C-terminal carboxyl O-methyltransferase activity
S-adenosylmethionine-dependent methyltransferase activity
regulation of mitotic spindle checkpoint
regulation of spindle checkpoint
C-terminal protein amino acid modification
regulation of mitotic cell cycle spindle assembly checkpoint
regulation of cell cycle checkpoint
regulation of mitotic metaphase/anaphase transition
regulation of metaphase/anaphase transition of cell cycle
regulation of mitotic sister chromatid separation
regulation of chromosome separation
regulation of mitotic sister chromatid segregation
regulation of sister chromatid segregation
regulation of chromosome segregation
regulation of glucose metabolic process
G2/M transition of mitotic cell cycle
negative regulation of protein complex assembly
cell cycle G2/M phase transition
protein methylation
protein alkylation
regulation of cellular carbohydrate metabolic process
regulation of mitotic nuclear division
regulation of nuclear division
regulation of carbohydrate metabolic process
macromolecule methylation
mitotic cell cycle phase transition
cell cycle phase transition
methylation
regulation of chromosome organization
post-translational protein modification
regulation of mitotic cell cycle phase transition
regulation of small molecule metabolic process
regulation of cell cycle phase transition
regulation of protein complex assembly
mitotic cell cycle process
regulation of mitotic cell cycle
mitotic cell cycle
negative regulation of cellular component organization