LCMT1 [The Human Chemical-Genetic Interaction Map Project]

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======= LCMT1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: LCMT1
  * **<color #00a2e8>Official Name</color>**: leucine carboxyl methyltransferase 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=51451|51451]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9UIC8|Q9UIC8]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=LCMT1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20LCMT1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/610286|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Methylates the carboxyl group of the C-terminal leucine residue of protein phosphatase 2A catalytic subunits to form alpha-leucine ester residues. {ECO:0000269|PubMed:10600115}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|LCM|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|protein C-terminal leucine carboxyl O-methyltransferase activity|
|C-terminal protein methylation|
|protein C-terminal carboxyl O-methyltransferase activity|
|S-adenosylmethionine-dependent methyltransferase activity|
|regulation of mitotic spindle checkpoint|
|regulation of spindle checkpoint|
|C-terminal protein amino acid modification|
|regulation of mitotic cell cycle spindle assembly checkpoint|
|regulation of cell cycle checkpoint|
|regulation of mitotic metaphase/anaphase transition|
|regulation of metaphase/anaphase transition of cell cycle|
|regulation of mitotic sister chromatid separation|
|regulation of chromosome separation|
|regulation of mitotic sister chromatid segregation|
|regulation of sister chromatid segregation|
|regulation of chromosome segregation|
|regulation of glucose metabolic process|
|G2/M transition of mitotic cell cycle|
|negative regulation of protein complex assembly|
|cell cycle G2/M phase transition|
|protein methylation|
|protein alkylation|
|regulation of cellular carbohydrate metabolic process|
|regulation of mitotic nuclear division|
|regulation of nuclear division|
|regulation of carbohydrate metabolic process|
|macromolecule methylation|
|mitotic cell cycle phase transition|
|cell cycle phase transition|
|methylation|
|regulation of chromosome organization|
|post-translational protein modification|
|regulation of mitotic cell cycle phase transition|
|regulation of small molecule metabolic process|
|regulation of cell cycle phase transition|
|regulation of protein complex assembly|
|mitotic cell cycle process|
|regulation of mitotic cell cycle|
|mitotic cell cycle|
|negative regulation of cellular component organization|
|regulation of cell cycle process|
|regulation of cellular component biogenesis|
|cell cycle process|
|regulation of cell cycle|
|regulation of organelle organization|
|cell cycle|
|regulation of apoptotic process|
|regulation of programmed cell death|
|regulation of cell death|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp480|ETC-159 50μM R08 exp480]]|-3.93|
|[[:results:exp125|GSK461364A 0.005μM R03 exp125]]|-3.19|
|[[:results:exp303|39°C R06 exp303]]|-3.18|
|[[:results:exp75|MK-1775 0.32μM R02 exp75]]|-2.71|
|[[:results:exp264|Arsenate 40μM R06 exp264]]|-2.68|
|[[:results:exp432|YM155 0.001μM R08 exp432]]|-2.65|
|[[:results:exp97|BI-6727 0.0125μM R03 exp97]]|-2.58|
|[[:results:exp95|BI-2536 0.0042μM R03 exp95]]|-2.5|
|[[:results:exp190|Vincristine 0.0005μM R04 exp190]]|-2.35|
|[[:results:exp227|Cryptotanshinone 12μM R05 exp227]]|-2.34|
|[[:results:exp292|Menadione 5μM R06 exp292]]|-2.22|
|[[:results:exp453|B02 10μM R08 exp453]]|-2.19|
|[[:results:exp78|Pterostilbene 16μM R02 exp78]]|-2.11|
|[[:results:exp211|AICAR 240μM R05 exp211]]|-1.86|
|[[:results:exp210|LB-100 2μM R05 exp210]]|-1.83|
|[[:results:exp116|AICAR 240μM R03 exp116]]|-1.82|
|[[:results:exp34|Rotenone 20μM R00 exp34]]|1.84|
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|2|
|[[:results:exp38|Wortmannin 5μM R00 exp38]]|2.34|
|[[:results:exp46|HMS-I1 1μM R01 exp46]]|2.87|
|[[:results:exp80|RO-3307 4.7μM R02 exp80]]|3|
|[[:results:exp311|2-Methoxyestradiol 0.55 to 0.75μM  on day4 R07 exp311]]|3.1|
|[[:results:exp460|BML-284 0.09μM R08 exp460]]|3.12|
|[[:results:exp357|Dorsomorphin 5μM R07 exp357]]|3.32|
|[[:results:exp312|2-Methoxyestradiol 0.55 to 1μM on day4 R07 exp312]]|5.04|
|[[:results:exp67|BVD-523 15μM R02 exp67]]|5.45|
|[[:results:exp59|UMK57 1μM R01 exp59]]|5.73|
|[[:results:exp502|Milciclib 2μM R08 exp502]]|5.75|
|[[:results:exp217|Mdivi-1 15μM R05 exp217]]|6.45|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:ppp2r1a|PPP2R1A]]|0.721|
|[[:human genes:p:ppme1|PPME1]]|0.656|
|[[:human genes:t:tiprl|TIPRL]]|0.604|
|[[:human genes:p:ppp2r4|PPP2R4]]|0.595|
|[[:human genes:p:ppp2r5c|PPP2R5C]]|0.49|
|[[:human genes:p:ppp2r2a|PPP2R2A]]|0.47|
|[[:human genes:p:ppp6c|PPP6C]]|0.459|
|[[:human genes:c:cbx3|CBX3]]|0.446|
|[[:human genes:c:cyb5r4|CYB5R4]]|0.433|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 41/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|1/28|
|blood|1/28|
|bone|0/26|
|breast|1/33|
|central nervous system|2/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|1/16|
|kidney|2/21|
|liver|0/20|
|lung|2/75|
|lymphocyte|1/16|
|ovary|4/26|
|pancreas|2/24|
|peripheral nervous system|0/16|
|plasma cell|2/15|
|prostate|0/1|
|skin|7/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2646
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.61 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='LCMT1 Expression in NALM6 Cells: 3.61'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>