PPP2R4

Gene Information

Official Symbol: PTPA
Official Name: protein phosphatase 2 phosphatase activator
Aliases and Previous Symbols: N/A
Entrez ID: 5524
UniProt: Q15257
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: Protein phosphatase 2A is one of the four major Ser/Thr phosphatases and is implicated in the negative control of cell growth and division. Protein phosphatase 2A holoenzymes are heterotrimeric proteins composed of a structural subunit A, a catalytic subunit C, and a regulatory subunit B. The regulatory subunit is encoded by a diverse set of genes that have been grouped into the B/PR55, B'/PR61, and B''/PR72 families. These different regulatory subunits confer distinct enzymatic specificities and intracellular localizations to the holozenzyme. The product of this gene belongs to the B' family. This gene encodes a specific phosphotyrosyl phosphatase activator of the dimeric form of protein phosphatase 2A. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008].
UniProt Summary: N/A

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
ABT-702 5μM plus Deferoxamine 11μM R07 exp321	-1.88
Centrinone 0.5μM R07 exp343	1.71
VER-155008 3.9μM R06 exp301	1.78
Oligomycin-A 2μM R00 exp25	1.83
BVD-523 15μM R02 exp67	1.9
Quinacrine 2.5μM R03 exp146	2.02
Mdivi-1 15μM R05 exp217	2.3
Milciclib 2μM R08 exp502	2.95
UMK57 1μM R01 exp59	3.37
RO-3307 4.7μM R02 exp80	4.07

Global Fraction of Cell Lines Where Essential: 336/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	15/28
blood	9/28
bone	11/26
breast	11/33
central nervous system	19/56
cervix	2/4
colorectal	10/17
esophagus	5/13
fibroblast	1/1
gastric	7/16
kidney	5/21
liver	8/20
lung	32/75
lymphocyte	6/16
ovary	11/26
pancreas	15/24
peripheral nervous system	6/16
plasma cell	6/15
prostate	0/1
skin	14/24
soft tissue	3/9
thyroid	2/2
upper aerodigestive	11/22
urinary tract	15/29
uterus	4/5

Essentiality in NALM6

Essentiality Rank: 1221
Expression level (log2 read counts): 6.43

Expression Distribution

Gene	Correlation
TIPRL	0.682
LCMT1	0.595
CYB5R4	0.584
PPME1	0.583
PPP6C	0.523
PPP6R3	0.464
PPP2R1A	0.461

protein tyrosine phosphatase activator activity
protein phosphatase type 2A complex
positive regulation of phosphoprotein phosphatase activity
calcium channel complex
protein phosphatase 2A binding
protein phosphatase regulator activity
positive regulation of phosphatase activity
positive regulation of protein dephosphorylation
peptidyl-prolyl cis-trans isomerase activity
protein peptidyl-prolyl isomerization
positive regulation of dephosphorylation
peptidyl-proline modification
negative regulation of phosphoprotein phosphatase activity
negative regulation of protein dephosphorylation
mitotic spindle organization
microtubule cytoskeleton organization involved in mitosis
negative regulation of phosphatase activity
negative regulation of dephosphorylation
regulation of phosphoprotein phosphatase activity
regulation of protein dephosphorylation
spindle organization
regulation of phosphatase activity
regulation of dephosphorylation
ATPase activity
signaling receptor binding
negative regulation of hydrolase activity
microtubule cytoskeleton organization
protein heterodimerization activity
negative regulation of phosphate metabolic process
negative regulation of phosphorus metabolic process
negative regulation of protein modification process
mitotic cell cycle process
positive regulation of apoptotic process
positive regulation of programmed cell death
microtubule-based process
mitotic cell cycle
positive regulation of cell death
positive regulation of hydrolase activity
negative regulation of catalytic activity
protein homodimerization activity