BCORL1

Entrez Summary: The protein encoded by this gene is a transcriptional corepressor that is found tethered to promoter regions by DNA-binding proteins. The encoded protein can interact with several different class II histone deacetylases to repress transcription. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2010].
UniProt Summary: Transcriptional corepressor. May specifically inhibit gene expression when recruited to promoter regions by sequence- specific DNA-binding proteins such as BCL6. This repression may be mediated at least in part by histone deacetylase activities which can associate with this corepressor. {ECO:0000269|PubMed:17379597}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
HMS-I1 1μM R01 exp46	-2.56
Docetaxel 0.002μM R01 exp45	-2.47
Taxol 0.002μM R01 exp54	-2.43
Vinblastine 0.002μM R01 exp60	-2.41
RS-1 10μM R08 exp519	-2.36
UM131593 0.1μM R01 exp58	-2.19
Suberoylanilide-Hydroxamic-Acid 0.02μM R01 exp53	-2.06
UMK57 1μM R01 exp59	-1.99
LLY-283 2.6μM R06 exp290	-1.9
NFN1 0.1μM R01 exp49	-1.84
Cisplatin 0.35μM R06 exp273	-1.83
2-Methoxyestradiol 0.55 to 1μM on day4 R07 exp312	-1.82
Staurosporine 0.02μM R08 exp524	-1.76
Lapatinib 5μM R01 exp47	-1.75

Global Fraction of Cell Lines Where Essential: 0/683

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/26
bone	0/25
breast	0/30
central nervous system	0/49
cervix	0/4
colorectal	0/17
esophagus	0/11
fibroblast	0/1
gastric	0/14
kidney	0/18
liver	0/19
lung	0/72
lymphocyte	0/14
ovary	0/25
pancreas	0/22
peripheral nervous system	0/15
plasma cell	0/12
prostate	0/1
skin	0/20
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/28
uterus	0/5

Expression Distribution

Ank 2
Ank

chromatin organization
chromosome organization